RND efflux pump systems in Acinetobacter, with special emphasis on their role in quorum sensing
- Author:
Bindu SUBHADRA
1
;
Man Hwan OH
;
Chul Hee CHOI
Author Information
- Publication Type:Review
- Keywords: Acinetobacter; RND efflux pumps; quorum sensing; quorum quenching
- MeSH: Acinetobacter; Anti-Infective Agents; Bacteria; Cross Infection; Drug Resistance, Microbial; Drug Resistance, Multiple; Prospective Studies; Quorum Sensing
- From:Journal of Bacteriology and Virology 2019;49(1):1-11
- CountryRepublic of Korea
- Language:English
- Abstract: Acinetobacter is an important opportunistic, multidrug resistant pathogen causing majority of nosocomial infections worldwide. The multidrug resistance is attributed by a plethora of efflux pumps and the overexpression of the same mediates export of antimicrobial agents. Quorum sensing (QS) is the cell-to-cell communication system in which bacteria produces specific signaling molecules which are transported out to the surrounding environment to communicate with other bacterial cells. It has been noticed that multidrug efflux pumps like resistance-nodulation-cell division (RND) efflux pumps play an important role in QS by exporting these signaling molecules. This review discusses various RND efflux pumps and the current understanding of the interrelationship of RND efflux pumps and QS in Acinetobacter spp. Studies demonstrate that RND efflux pumps could be considered as potential targets to block QS thereby reducing pathogenesis and antibiotic resistance. The known RND efflux pump-mediated quorum quenching strategies for Acinetobacter and other bacterial strains are discussed in detail. Finally, the prospective quorum quenching strategies targeting the transcriptional regulators of RND efflux pumps to inhibit multidrug efflux pumps are addressed.
