Regulation of Osteoclast Differentiation by Cytokine Networks
- Author:
Dulshara Sachini AMARASEKARA
1
;
Hyeongseok YUN
;
Sumi KIM
;
Nari LEE
;
Hyunjong KIM
;
Jaerang RHO
Author Information
- Publication Type:Review
- Keywords: Cytokines; Osteoclast differentiation factor; Osteoclastogenesis; Osteoimmunology
- MeSH: Cytokines; Homeostasis; Interferons; Interleukin-1; Interleukin-10; Interleukin-11; Interleukin-12; Interleukin-15; Interleukin-17; Interleukin-23; Interleukin-27; Interleukin-3; Interleukin-33; Interleukin-4; Interleukin-6; Interleukin-7; Interleukin-8; Macrophage Colony-Stimulating Factor; Necrosis; Osteoblasts; Osteoclasts; RANK Ligand
- From:Immune Network 2018;18(1):e8-
- CountryRepublic of Korea
- Language:English
- Abstract: Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand play a central role in OC differentiation, which is also termed osteoclastogenesis. Osteoclastogenic cytokines, including tumor necrosis factor-α, IL-1, IL-6, IL-7, IL-8, IL-11, IL-15, IL-17, IL-23, and IL-34, promote OC differentiation, whereas anti-osteoclastogenic cytokines, including interferon (IFN)-α, IFN-β, IFN-γ, IL-3, IL-4, IL-10, IL-12, IL-27, and IL-33, downregulate OC differentiation. Therefore, dynamic regulation of osteoclastogenic and anti-osteoclastogenic cytokines is important in maintaining the balance between bone-resorbing OCs and bone-forming osteoblasts (OBs), which eventually affects bone integrity. This review outlines the osteoclastogenic and anti-osteoclastogenic properties of cytokines with regard to osteoimmunology, and summarizes our current understanding of the roles these cytokines play in osteoclastogenesis.
