Out-sourcing for Trans-presentation: Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
- Author:
Joo Young PARK
1
;
Davinna L LIGONS
;
Jung Hyun PARK
Author Information
- Publication Type:Review
- Keywords: Cytokine receptor; Inflammation; Th17 cells; Cytokine signaling
- MeSH: Animals; Cell Differentiation; Dendritic Cells; Homeostasis; Humans; In Vitro Techniques; Inflammation; Interleukin-15; Memory; Mice; Myeloid Cells; Receptors, Cytokine; Stromal Cells; T-Lymphocyte Subsets; T-Lymphocytes; Th17 Cells
- From:Immune Network 2018;18(1):e13-
- CountryRepublic of Korea
- Language:English
- Abstract: IL-15 is a cytokine of the common γ-chain family that is critical for natural killer (NK), invariant natural killer T (iNKT), and CD8 memory T cell development and homeostasis. The role of IL-15 in regulating effector T cell subsets, however, remains incompletely understood. IL-15 is mostly expressed by stromal cells, myeloid cells, and dendritic cells (DCs). Whether T cells themselves can express IL-15, and if so, whether such T cell-derived IL-15 could play an autocrine role in T cells are interesting questions that were previously addressed but answered with mixed results. Recently, three independent studies described the generation of IL-15 reporter mice which facilitated the identification of IL-15-producing cells and helped to clarify the role of IL-15 both in vitro and in vivo. Here, we review the findings of these studies and place them in context of recent reports that examined T cell-intrinsic IL-15 expression during CD4 effector T cell differentiation.
