Regulation of Allergic Immune Responses by Microbial Metabolites
- Author:
Hyun Jung PARK
1
;
Sung Won LEE
;
Seokmann HONG
Author Information
- Publication Type:Review
- Keywords: Microbial metabolites; Dermatitis, atopic; Food allergy; Poly-γ-glutamic acid; iNKT cells
- MeSH: Architectural Accessibility; Dermatitis, Atopic; Epithelium; Fatty Acids, Volatile; Food Hypersensitivity; Microbiota; Natural Killer T-Cells
- From:Immune Network 2018;18(1):e15-
- CountryRepublic of Korea
- Language:English
- Abstract: Emerging evidence demonstrates that the microbiota plays an essential role in shaping the development and function of host immune responses. A variety of environmental stimuli, including foods and commensals, are recognized by the host through the epithelium, acting as a physical barrier. Two allergic diseases, atopic dermatitis and food allergy, are closely linked to the microbiota, because inflammatory responses occur on the epidermal border. The microbiota generates metabolites such as short-chain fatty acids and poly-γ-glutamic acid (γPGA), which can modulate host immune responses. Here, we review how microbial metabolites can regulate allergic immune responses. Furthermore, we focus on the effect of γPGA on allergic T helper (Th) 2 responses and its therapeutic application.
