Survival benefit of patients with early-stage ovarian carcinoma treated with paclitaxel chemotherapeutic regimens
- Author:
Chien An CHEN
1
;
Chun Ju CHIANG
;
Yun Yuan CHEN
;
San Lin YOU
;
Shu Feng HSIEH
;
Chao Hsiun TANG
;
Wen Fang CHENG
Author Information
- Publication Type:Original Article
- Keywords: Ovarian Neoplasms; Drug Therapy; Taxane; Disease-Free Survival; Survival
- MeSH: Chemotherapy, Adjuvant; Cyclophosphamide; Disease-Free Survival; Drug Therapy; Humans; National Health Programs; Ovarian Neoplasms; Paclitaxel; Platinum; Taiwan
- From:Journal of Gynecologic Oncology 2018;29(1):e16-
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: Adjuvant chemotherapy was introduced in patients with early-stage ovarian cancer (OC). The benefit of standard chemotherapeutic regimens including taxane has not been established. METHODS: Patients with early-stage OC from the National Health Insurance Research database of Taiwan who received platinum plus cyclophosphamide (CP) or platinum plus paclitaxel (PT) for 3–6 cycles were recruited, and the disease-free survival (DFS) and overall survival (OS) were determined. RESULTS: A total of 1,510 early-stage OC patients, including 841 who received CP regimen and 699 who received PT regimen, were included. The 2 groups had a similar estimated probability of 5-year DFS (PT vs. CP, 79.0% vs. 77.6%; p=0.410) and OS (84.6% vs. 84.3%; p=0.691). Patients >50 years of age who received the CP regimen had a lower 5-year DFS than the patients ≤50 years of age who received the CP (p<0.001) or PT regimens (p=0.001). Additionally, patients >50 years of age who received the CP regimen had a worse 5-year OS compared with the other 3 groups (p=0.019) (p=0.179 for patients >50 years of age in the PT group; p=0.002 for patients ≤50 years of age in the CP group; and p=0.061 for patients ≤50 years of age in the PT group). Patients with the CP or PT regimen for 3–5 cycles had a similar 5-year DFS and OS compared to 6 cycles (p>0.050). CONCLUSION: Chemotherapeutic regimens with taxane could be recommended for early-stage OC patients >50 years of age.
