Dynamic Susceptibility Contrast (DSC) Perfusion MR in the Prediction of Long-Term Survival of Glioblastomas (GBM): Correlation with MGMT Promoter Methylation and 1p/19q Deletions
10.13104/imri.2018.22.3.158
- Author:
Yong Wonn KWON
1
;
Won Jin MOON
;
Mina PARK
;
Hong Gee ROH
;
Young Cho KOH
;
Sang Woo SONG
;
Jin Woo CHOI
Author Information
1. Department of Radiology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. cardijin@kuh.ac.kr
- Publication Type:Original Article
- Keywords:
Original research;
Glioblastoma;
Perfusion imaging;
Magnetic resonance image, Dynamic susceptibility contrast perfusion;
Radiogenomics
- MeSH:
Diagnosis;
Ethics Committees, Research;
Glioblastoma;
Humans;
Linear Models;
Methylation;
Perfusion Imaging;
Perfusion;
Prevalence;
Retrospective Studies;
Survivors
- From:Investigative Magnetic Resonance Imaging
2018;22(3):158-167
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate the surgical, perfusion, and molecular characteristics of glioblastomas which influence long-term survival after treatment, and to explore the association between MR perfusion parameters and the presence of MGMT methylation and 1p/19q deletions. MATERIALS AND METHODS: This retrospective study was approved by our institutional review board. A total 43 patients were included, all with pathologic diagnosis of glioblastoma with known MGMT methylation and 1p/19q deletion statuses. We divided these patients into long-term (≥ 60 months, n = 7) and short-term (< 60 months, n = 36) survivors, then compared surgical extent, molecular status, and rCBV parameters between the two groups using Fisher's exact test or Mann-Whitney test. The rCBV parameters were analyzed according to the presence of MGMT methylation and 1p/19q deletions. We investigated the relationship between the mean rCBV and overall survival using linear correlation. Multivariable linear regression was performed in order to find the variables related to overall survival. RESULTS: Long-term survivors (100% [7 of 7]) demonstrated a greater percentage of gross total or near total resection than short-term survivors (54.5% [18 of 33]). A higher prevalence of 1p/19q deletions was also noted among the long-term survivors (42.9% [3 of 7]) than the short-term survivors (0.0% [0 of 36]). The rCBV parameters did not differ between the long-term and short-term survivors. The rCBV values were marginally lower in patients with MGMT methylation and 1p/19q deletions. Despite no correlation found between overall survival and rCBV in the whole group, the short-term survivor group showed negative correlation (R2 = 0.181, P = 0.025). Multivariable linear regression revealed that surgical extent and 1p/19q deletions, but not rCBV values, were associated with prolonged overall survival. CONCLUSION: While preoperative rCBV and 1p/19q deletion status are related to each other, only surgical extent and the presence of 1p/19q deletion in GBM patients may predict long-term survival.
