Effect of Resveratrol on Cell Differentiation and Mineralization in Cultured Odontoblasts
10.11620/IJOB.2018.43.3.133
- Author:
Sang Hun SHIN
1
;
Jae Sung KIM
;
Su Gwan KIM
;
Dae San GO
;
Sun Kyoung YU
;
Chun Sung KIM
;
Joo Cheol PARK
;
Do Kyung KIM
Author Information
1. Oral Biology Research Institute, School of Dentistry, Chosun University, Gwangju 61452, Republic of Korea. kdk@chosun.ac.kr
- Publication Type:Original Article
- Keywords:
resveratrol;
odontoblasts;
differentiation;
mineralization
- MeSH:
Animals;
Cell Death;
Cell Differentiation;
Cell Proliferation;
Dental Papilla;
Dentin;
Diabetes Mellitus;
Inflammation;
Mice;
Miners;
Odontoblasts;
Regeneration;
RNA, Messenger;
Superoxides;
Vitis
- From:International Journal of Oral Biology
2018;43(3):133-140
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Resveratrol (3,4′,5,-trihydroxystilbene), a phytoalexin present in grapes, exerts a variety of actions to reduce superoxides, prevents diabetes mellitus, and inhibits inflammation. Resveratrol acts as a chemo-preventive agent and induces apoptotic cell death in various cancer cells. However, the role of resveratrol in odontoblastic cell differentiation is unclear. In this study, the effect of resveratrol on regulating odontoblast differentiation was examined in MDPC-23 mouse odontoblastic cells derived from mouse dental papilla cells. Resveratrol significantly accelerated mineralization as compared with the control culture in differentiation of MDPC-23 cells. Resveratrol significantly increased expression of ALP mRNA as compared with the control in differentiation of MDPC-23 cells. Resveratrol significantly accelerated expression of ColImRNA as compared with the control in differentiation of MDPC-23 cells. Resveratrol significantly increased expressions of DSPP and DMP-1 mRNAs as compared with the control in differentiation of MDPC-23 cells. Treatment of resveratrol did not significantly affect cell proliferation in MDPC-23 cells. Results suggest resveratrol facilitates odontoblast differentiation and mineralization in differentiation of MDPC-23 cells, and may have potential properties for development and clinical application of dentin regeneration materials.
