Role of neuron and non-neuronal cell communication in persistent orofacial pain
10.17245/jdapm.2019.19.2.77
- Author:
Koichi IWATA
1
;
Masamichi SHINODA
Author Information
1. Department of Physiology, Nihon University School of Dentistry, Tokyo, Japan. iwata.kouichi@nihon-u.ac.jp
- Publication Type:Review
- Keywords:
Cell Communication;
Orofacial Persistent Pain;
Spinal Trigeminal Nucleus;
Trigeminal Ganglion
- MeSH:
Cell Communication;
Cervical Cord;
Facial Pain;
Inflammation;
Macrophages;
Neurons;
Nociceptors;
Trigeminal Ganglion;
Trigeminal Nerve;
Trigeminal Nerve Injuries;
Trigeminal Nucleus, Spinal
- From:Journal of Dental Anesthesia and Pain Medicine
2019;19(2):77-82
- CountryRepublic of Korea
- Language:English
-
Abstract:
It is well known that trigeminal nerve injury causes hyperexcitability in trigeminal ganglion neurons, which become sensitized. Long after trigeminal nerve damage, trigeminal spinal subnucleus caudalis and upper cervical spinal cord (C1/C2) nociceptive neurons become hyperactive and are sensitized, resulting in persistent orofacial pain. Communication between neurons and non-neuronal cells is believed to be involved in these mechanisms. In this article, the authors highlight several lines of evidence that neuron-glial cell and neuron macrophage communication have essential roles in persistent orofacial pain mechanisms associated with trigeminal nerve injury and/or orofacial inflammation.
