Rapid onset of facial swelling - Answers.
- Author:
Noorainun MOHAMAD YUSOF
- Publication Type:Journal Article
- From:Brunei International Medical Journal
2010;6(1):72-72
- CountryBrunei Darussalam
- Language:English
-
Abstract:
(Refer to page 51)
Answer: Spontaneous bilateral periorbital
haematoma associated with
acute promyelocytic leukemia
In this patient, the spontaneous bilateral periorbital
haematoma could be due to severe
thrombocytopenia. However the presence of
abnormal promyelocytes in the peripheral
blood smear (Panel, darkly stained cells
are promyelocytes) is suggestive of acute
promyelocytic leukemia (APL) which should
be confirmed with a bone marrow biopsy,
cytogenetic study for t(15;17) and molecular
study for PML-RARa oncogene fusion.
