Randomized controlled trial to compare oral analgesic requirements and patient satisfaction in using oral non-steroidal anti-inflammatory drugs versus benzydamine hydrochloride oral rinses after mandibular third molar extraction: a pilot study
10.17245/jdapm.2018.18.1.19
- Author:
Devalina GOSWAMI
1
;
Gaurav JAIN
;
Mangesh MOHOD
;
Dalim Kumar BAIDYA
;
Ongkila BHUTIA
;
Ajoy ROYCHOUDHURY
Author Information
1. Department of Anesthesiology, Pain Medicine and Critical Care, Indial Institute of Medical sciences, New Delhi, India. drdevalina@gmail.com
- Publication Type:Randomized Controlled Trial
- Keywords:
Benzydamine Hydrochloride;
Third Molar;
Tooth Extraction;
Topical Application
- MeSH:
Acetaminophen;
Analgesics;
Benzydamine;
Humans;
Ibuprofen;
Molar, Third;
Pain, Postoperative;
Patient Satisfaction;
Pilot Projects;
Tooth Extraction;
Trismus
- From:Journal of Dental Anesthesia and Pain Medicine
2018;18(1):19-25
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Third molar extraction is associated with considerable pain and discomfort, which is mostly managed with oral analgesic medication. We assessed the analgesic effect of benzydamine hydrochloride, a topical analgesic oral rinse, for controlling postoperative pain following third molar extraction. METHODS: A randomized controlled trial was conducted in 40 patients divided into two groups, for extraction of fully erupted third molar. Groups A received benzydamine hydrochloride mouthwash and group B received normal saline gargle with oral ibuprofen and paracetamol. Oral ibuprofen and paracetamol was the rescue analgesic drug in group A. Patients were evaluated on the 3(rd) and 7(th) post-operative days (POD) for pain using the visual analogue score (VAS), trismus, total number of analgesics consumed, and satisfaction level of patients. RESULTS: The VAS in groups A and B on POD3 and POD7 was 4.55 ± 2.54 and 3.95 ± 1.8, and 1.2 ± 1.64 and 0.95 ± 1.14, respectively and was statistically insignificant. The number of analgesics consumed in groups A and B on POD3 (5.25 ± 2.22 and 6.05 ± 2.43) was not statistically different from that consumed on POD7 (9.15 ± 5.93 and 10.65 ± 6.46). The p values for trismus on POD3 and POD7 were 0.609 and 0.490, respectively and those for patient satisfaction level on POD3 and POD7 were 0.283 and 0.217, respectively. CONCLUSIONS: Benzydamine hydrochloride oral rinses do not significantly reduce intake of oral analgesics and are inadequate for pain relief following mandibular third molar extraction.
