Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical Trial
- Author:
Jian ZHANG
1
;
Samei LV
;
Xiaojing LIU
;
Bin SONG
;
Liping SHI
Author Information
- Publication Type:Clinical Trial
- Keywords: Umbilical cord; Mesenchymal stromal cells; Crohn disease; Cellular therapy; Autoimmune
- MeSH: Autoimmune Diseases; Crohn Disease; Fever; Humans; Infusions, Intravenous; Mesenchymal Stromal Cells; Stem Cells; Umbilical Cord
- From:Gut and Liver 2018;12(1):73-78
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Stem cell therapy has been applied to treat a variety of autoimmune diseases, including Crohn's disease (CD), but few studies have examined the use of umbilical cord mesenchymal stem cells (UC-MSCs). This trial sought to investigate the efficacy and safety of UC-MSCs for the treatment of CD. METHODS: Eighty-two patients who had been diagnosed with CD and had received steroid maintenance therapy for more than 6 months were included in this study. Forty-one patients were randomly selected to receive a total of four peripheral intravenous infusions of 1×106 UC-MSCs/kg, with one infusion per week. Patients were followed up for 12 months. The Crohn's disease activity index (CDAI), Harvey-Bradshaw index (HBI), and corticosteroid dosage were assessed. RESULTS: Twelve months after treatment, the CDAI, HBI, and corticosteroid dosage had decreased by 62.5±23.2, 3.4±1.2, and 4.2±0.84 mg/day, respectively, in the UC-MSC group and by 23.6±12.4, 1.2±0.58, and 1.2±0.35 mg/day, respectively, in the control group (p < 0.01, p < 0.05, and p < 0.05 for UC-MSC vs control, respectively). Four patients developed a fever after cell infusion. No serious adverse events were observed. CONCLUSIONS: UC-MSCs were effective in the treatment of CD and produced mild side effects.
