Urologic Applications of Cryo-Immunology.
10.4111/kju.2009.50.7.629
- Author:
Abhinav SIDANA
1
;
Ronald RODRIGUEZ
Author Information
1. Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. RRodriguez@jhmi.edu
- Publication Type:Review
- Keywords:
Cryosurgery;
Prostatic neoplasms;
Kidney neoplasms;
Immunotherapy
- MeSH:
Cryosurgery;
Immunotherapy;
Kidney Neoplasms;
Models, Animal;
Prostatic Neoplasms;
Salvage Therapy
- From:Korean Journal of Urology
2009;50(7):629-634
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Cryoablation is gaining acceptance as a primary treatment of localized metastatic urologic malignancies as well as a salvage therapy. Anecdotal clinical reports suggest that cryoablation can induce a systemic antitumor immune response, which has been confirmed in animal models also. MATERIALS AND METHODS: A review of the relevant literature was performed to suggest urologic applications of cryo-immunology. RESULTS: This article reviews the existing evidence regarding cryo-immunology and discusses the mechanisms for generation of an anti-tumor immune response. CONCLUSIONS: Our findings suggest combining cryoablation with other immunotherapeutic approaches to devise a cryo-immunotherapeutic strategy with potential to impact the progression of metastatic disease.
