Antipsychotic Effects of Quetiapine in Naturalistic Long Term Follow Up Study.
- Author:
Jung Sun LEE
1
;
Joon Ho AHN
;
Do Hoon KIM
;
Jong Jin KIM
;
Tae Young KIM
;
So Young YOO
;
Dong Geun LEE
;
Sang Hyuk LEE
;
Se Won LIM
;
Weon Jeong LIM
;
Il Kyung JUNG
;
Hae Kyung JUNG
;
Dong Hwan CHO
;
In Hee CHO
;
Chang Yoon KIM
Author Information
1. Department of Psychiatry, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. cykim@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Quetiapine;
Naturalistic study;
High-dose
- MeSH:
Antipsychotic Agents;
Diagnostic and Statistical Manual of Mental Disorders;
Dibenzothiazepines;
Follow-Up Studies;
Humans;
Psychotic Disorders;
Schizophrenia;
Quetiapine Fumarate
- From:Psychiatry Investigation
2010;7(2):128-134
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study aimed to examine the effectiveness of quetiapine and the effects of dosage relates to its effectiveness on schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people. METHODS: This study was a 24-week, open-label, non-comparative, naturalistic study of quetiapine in patients diagnosed with schizophrenia and schizoaffective disorder according to DSM-IV. We stratified the patients into mild [(clinical global impression severity (CGI-S) <4 at baseline)] and severe groups (CGI-S > or =4 at baseline). We investigated the response rate, defined as clinical global impression improvement (CGI-I) < or =2, in the severe group and the aggravation rate in the mild group using the last-observation-carried-forward (LOCF) and the Kaplan-Meier method (K-M). RESULTS: During the 24 weeks, 151 (18.4%) of the participants dropped out of the study. There was a significant decrease in the mean CGI-S score, from 4.5+/-1.1 at baseline to 2.8+/-1.1 at 24 weeks. The response rate of severe group was 54.5% (estimated by LOCF) and 73.3% (K-M estimated) at 24 weeks. All patients who completed the study had taken a mean quetiapine dosage of 507.9+/-245.9 mg daily. The decrease of CGI-S score in high-dose group (the maximum dose was 750 mg/d or above) was statistically significant than that in recommended-dose group (the maximum dose was less than 750 mg/d). CONCLUSION: This study demonstrated the long-term effectiveness of quetiapine in the treatment of schizophrenia and schizoaffective disorder in a naturalistic setting in Korean people. This study suggests that higher than recommended quetiapine dosages could be more effective in some patients.
