Second Primary Cancer Risk among Kidney Cancer Patients in Korea: A Population-Based Cohort Study
- Author:
Jae Young JOUNG
1
;
Whi An KWON
;
Jiwon LIM
;
Chang Mo OH
;
Kyu Won JUNG
;
Sung Han KIM
;
Ho Kyung SEO
;
Weon Seo PARK
;
Jinsoo CHUNG
;
Kang Hyun LEE
;
Young Joo WON
Author Information
- Publication Type:Original Article
- Keywords: Renal cell carcinoma; Second primary neoplasms; Prognosis; Incidence; Survival
- MeSH: Carcinoma, Renal Cell; Cohort Studies; Diagnosis; Education; Female; Follow-Up Studies; Humans; Incidence; Kidney Neoplasms; Kidney; Korea; Male; Neoplasms, Second Primary; Prognosis; Stomach Neoplasms
- From:Cancer Research and Treatment 2018;50(1):293-301
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: Secondary primary cancers (SPCs) commonly arise in patients with renal cell carcinoma (RCC). We designed the present study to estimate the SPC incidence in Korean patients with RCC. MATERIALS AND METHODS: The study cohort was population-based and consisted of 40,347 individuals from the Korean Central Cancer Registry who were diagnosed with primary renal cancer between 1993 and 2013. Standardized incidence ratios (SIRs) for SPCs were estimated for different ages at diagnosis, latencies, diagnostic periods, and treatments. RESULTS: For patients with primary RCC, the risk of developing a SPC was higher than the risk of developing cancer in the general population (SIR, 1.13; 95% confidence interval, 1.08 to 1.18). Most cancer types showed higher incidences in patients with RCC than in the general population. However, the relative incidence of gastric cancer as an SPC varied by age. Gastric cancer incidence was elevated in young patients (< 30 years) with RCC, but reduced in older (≥ 30) patients with RCC. Patients with advanced RCC died prematurely, regardless of SPC development. In contrast, those with early-stage RCC survived for longer periods, although SPC development affected their post-RCC survival. After SPC development, women had better survival than men. CONCLUSION: In Korean patients with primary RCC, the incidence of SPC was 13% higher than the incidence of cancer in the general population. These findings may play important roles in the conduct of follow-up evaluations and education for patients with RCC.
