Incidence and risk factors for herpes zoster after adult liver transplantation
10.4174/astr.2019.96.2.95
- Author:
Wontae KIM
1
;
Sangjin KIM
;
Jongwook OH
;
Young Jae JEONG
;
Jinsoo RHU
;
Kyung Sik KIM
;
Jisoo LEE
;
Gyu Sung CHOI
;
Jong Man KIM
;
Jae Won JOH
Author Information
1. Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. yjongman21@gmail.com
- Publication Type:Original Article
- Keywords:
Herpes zoster;
Incidence;
Liver transplantation;
Risk factors
- MeSH:
Adult;
Herpes Zoster;
Herpesvirus 3, Human;
Humans;
Immunity, Cellular;
Immunosuppression;
Incidence;
Liver Transplantation;
Liver;
Retrospective Studies;
Risk Factors;
Transplant Recipients
- From:Annals of Surgical Treatment and Research
2019;96(2):95-99
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Herpes zoster (HZ) is caused by reactivation of the varicella zoster virus, which occurs frequently in liver transplant recipients with impaired cellular immunity. The purpose of this study was to evaluate the incidence and risk factors for HZ after adult liver transplantation (LT). METHODS: In our institution, 993 patients underwent adult LT from January 1997 to December 2013. We retrospectively analyzed the incidence rate of HZ and risk factors for HZ after LT. RESULTS: Of 993 LT recipients, 101 (10.2%) were diagnosed with HZ. The incidence of HZ at 1, 3, 5, and 10 years was 6.6%, 9.1%, 10.0%, and 11.9%, respectively. Therefore, we observed that the incidence of HZ after LT was 16.3 per 1,000 person-years. Older age (≥50 years) at LT and mycophenolate mofetil (MMF) exposure were independent risk factors of HZ infection after adult LT. CONCLUSION: Patients older than 50 years or with MMF exposure are considered to be at high risk for HZ. Therefore, adult liver recipients with such factors should not be given strong immunosuppression treatments.
