14-3-3γ Haploinsufficient Mice Display Hyperactive and Stress-sensitive Behaviors
- Author:
Do Eon KIM
1
;
Chang Hoon CHO
;
Kyoung Mi SIM
;
Osung KWON
;
Eun Mi HWANG
;
Hyung Wook KIM
;
Jae Yong PARK
Author Information
- Publication Type:Original Article
- Keywords: 14-3-3γ; Ywhag; Hyperactivity; Anxiety; Acute stress; ADHD
- MeSH: Animals; Anxiety; Brain; Heterozygote; Mice; Mice, Knockout; Williams Syndrome
- From:Experimental Neurobiology 2019;28(1):43-53
- CountryRepublic of Korea
- Language:English
- Abstract: 14-3-3γ plays diverse roles in different aspects of cellular processes. Especially in the brain where 14-3-3γ is enriched, it has been reported to be involved in neurological and psychiatric diseases (e.g. Williams-Beuren syndrome and Creutzfeldt-Jakob disease). However, behavioral abnormalities related to 14-3-3γ deficiency are largely unknown. Here, by using 14-3-3γ deficient mice, we found that homozygous knockout mice were prenatally lethal, and heterozygous mice showed developmental delay relative to wild-type littermate mice. In addition, in behavioral analyses, we found that 14-3-3γ heterozygote mice display hyperactive and depressive-like behavior along with more sensitive responses to acute stress than littermate control mice. These results suggest that 14-3-3γ levels may be involved in the developmental manifestation of related neuropsychiatric diseases. In addition, 14-3-3γ heterozygote mice may be a potential model to study the molecular pathophysiology of neuropsychiatric symptoms.
