Seasonal patterns and etiologies of croup in children during the period 2010–2015: A multicenter retrospective study
- Author:
Yong Ju LEE
1
;
Hyo Bin KIM
;
Bong Seong KIM
;
Chang Keun KIM
;
Cheol Hong KIM
;
Hyung Young KIM
;
Sangyoung KIM
;
Yunsun KIM
;
Chorong PARK
;
Ju Hee SEO
;
In Suk SOL
;
Myongsoon SUNG
;
Min Seob SONG
;
Dae Jin SONG
;
Young Min AHN
;
Hea Lin OH
;
Jinho YU
;
Kyung Suk LEE
;
Eun LEE
;
Ju Suk LEE
;
Gwang Cheon JANG
;
Yoon Young JANG
;
Eun Hee CHUNG
;
Hai Lee CHUNG
;
Sung Min CHOI
;
Yun Jung CHOI
;
Man Yong HAN
;
Hyeon Jong YANG
;
Jung Yeon SHIM
;
Jin Tack KIM
;
Author Information
- Publication Type:Multicenter Study
- Keywords: Child; Croup; Hospitalization; Retrospective studies; Seasons
- MeSH: Child; Coronavirus; Croup; Demography; Electronic Health Records; Hospitalization; Humans; Korea; Male; Mycoplasma; Paramyxoviridae Infections; Polymerase Chain Reaction; Respiratory Syncytial Viruses; Retrospective Studies; Reverse Transcription; Rhinovirus; Seasons
- From:Allergy, Asthma & Respiratory Disease 2019;7(2):78-85
- CountryRepublic of Korea
- Language:Korean
- Abstract: PURPOSE: Croup is known to have epidemics in seasonal and biennial trends, and to be strongly associated with epidemics of parainfluenza virus. However, seasonal and annual epidemics of croup have not been clearly reported in Korea. This study aimed to examine the seasonal/annual patterns and etiologies of childhood croup in Korea during a consecutive 6-year period. METHODS: Pediatric croup data were collected from 23 centers in Korea from 1 January 2010 to 31 December 2015. Electronic medical records, including multiplex reverse transcription polymerase chain reaction (RT-PCR) results, demographics and clinical information were cross-sectionally reviewed and analyzed. RESULTS: Overall, 2,598 childhood croup patients requiring hospitalization were identified during the study period. Among them, a total of 927 who underwent RT-PCR were included in the analysis. Males (61.5%) predominated, and most (63.0%) of them were younger than 2 years of age (median, 19 months; interquartile range, 11–31 months). Peak hospitalization occurred in 2010 and 2012 in even-numbered years, and parainfluenza virus (PIV, 39.7%) was the most common cause of childhood croup requiring hospitalization, followed by respiratory syncytial virus (14.9%), human rhinovirus (12.5%), Mycoplasma pneumonaie (10.6%), and human coronavirus (7.3%). CONCLUSION: It is concluded that croup hospitalization has a biennial pattern in even-numbered years. PIV may be the most common cause of childhood croup; however, croup epidemics could be attributed to other viruses.
