Critical effects of long non-coding RNA on fibrosis diseases
- Author:
Yue ZHANG
1
;
Gang LUO
;
Yi ZHANG
;
Mengjie ZHANG
;
Jian ZHOU
;
Weiwu GAO
;
Xiuyun XUAN
;
Xia YANG
;
Di YANG
;
Zhiqiang TIAN
;
Bing NI
;
Jun TANG
Author Information
- Publication Type:Review
- MeSH: Autoimmune Diseases; Fibrosis; Genetic Diseases, Inborn; Humans; Kidney; Liver; Lung; Metabolic Diseases; Myocardium; Pathology; Peritoneum; RNA, Long Noncoding
- From:Experimental & Molecular Medicine 2018;50(1):e428-
- CountryRepublic of Korea
- Language:English
- Abstract: The expression or dysfunction of long non-coding RNAs (lncRNAs) is closely related to various hereditary diseases, autoimmune diseases, metabolic diseases and tumors. LncRNAs were also recently recognized as functional regulators of fibrosis, which is a secondary process in many of these diseases and a primary pathology in fibrosis diseases. We review the latest findings on lncRNAs in fibrosis diseases of the liver, myocardium, kidney, lung and peritoneum. We also discuss the potential of disease-related lncRNAs as therapeutic targets for the clinical treatment of human fibrosis diseases.
