Epidural Ketamine for Control of Postoperative Pain.
10.4097/kjae.1987.20.3.354
- Author:
Ryung CHOI
1
;
Nam Sik WOO
;
Dae Ja UM
;
Hae Keum KIL
Author Information
1. Department of Anesthesiology, Wonju Medical College, Yonsei University, Korea.
- Publication Type:Original Article
- MeSH:
Analgesics, Opioid;
Depression;
Epidural Space;
Ketamine*;
Pain, Postoperative*;
Respiratory Insufficiency
- From:Korean Journal of Anesthesiology
1987;20(3):354-357
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
In recent years the use of epidural opiates has increased and although this method of pain relief has shown good results in clinical practice it is still subject to certain drowba-cks, the most serious of which appears to be delayed respiratory depression. Since ketamine administered systemically is unlikely to produce respiratory depression it seemed worthwhile to investigate the possibility of exploiting the potent analgesic property to ketarnine by its epidural administration. The analgesic effect of ketamine 4 mg, administered epidural space, was evaluated. The duration of pain relief varied from less than 3 hours in 20% to over 24 hours in 30 % of the cases. In 62.5% of the cases pain relief exceeded 6 hours. There was no evidence of respiratery depression, and there no postoperative neurologic sequelae. The present results indicated the need for farther studios to compare the efficacy and safety of epidural ketamine with the response to epidural opioids for the relief of posto- peratiue pain.
