A Pediatric Case of Inflammatory Bowel Disease with Renal Amyloidosis
10.3339/jkspn.2018.22.2.81
- Author:
Hyesun HYUN
1
;
Eujin PARK
;
Ji Hyun KIM
;
Myung Hyun CHO
;
Hee Gyung KANG
;
Jin Soo MOON
;
Kyung Chul MOON
;
Il Soo HA
;
Hae Il CHEONG
Author Information
1. Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Korea. Cheonghi@snu.ac.kr
- Publication Type:Case Report
- Keywords:
Renal amyloidosis;
Crohn's disease;
Very early onset inflammatory bowel disease
- MeSH:
Amyloidosis;
Colitis, Ulcerative;
Crohn Disease;
Disease Progression;
Humans;
Inflammatory Bowel Diseases;
Infliximab;
Rare Diseases
- From:Childhood Kidney Diseases
2018;22(2):81-85
- CountryRepublic of Korea
- Language:English
-
Abstract:
Amyloidosis is a rare disease that results from the deposition of extracellular protein in various body tissues, causing progressive organ dysfunction. Secondary renal amyloidosis is a rare but serious complication of chronic inflammatory bowel disease, particularly in patients with Crohn's disease or ulcerative colitis. We report a case of secondary renal amyloidosis in a pediatric patient who reported a 16-year history of “very early onset inflammatory bowel disease”. Intensive treatment including repeated infliximab infusions improved clinical parameters of inflammatory bowel disease, although renal dysfunction showed progression. Amyloidosis should be considered in patients with IBD, particularly if they suffered disease progression.
