A Case of Alloimmune Neonatal Neutropenia.
- Author:
Yong Hee LEE
1
;
Ji Eun LEE
;
Jun Ho HUH
;
Oh Hyuk KWON
;
Ae Suk KIM
Author Information
1. Department of Pediatrics, Pohang St. Mary's Hospital, Pohang, Korea.
- Publication Type:Case Report
- Keywords:
Alloimmune neonatal neutropenia;
IVIG
- MeSH:
Anti-Bacterial Agents;
Antibodies;
Diagnosis;
Female;
Fluorescent Antibody Technique, Indirect;
Humans;
Immunoglobulin G;
Immunoglobulins;
Immunoglobulins, Intravenous;
Infant, Newborn;
Neutropenia*;
Neutrophils;
Placenta
- From:Journal of the Korean Society of Neonatology
1999;6(2):276-279
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Alloimmune neonatal neutropenia (ANN) is due to maternal IgG neutrophil-specific antibodies that cross the placenta to sensitize fetal neutrophils and cause neutropenia in the neonate. Infection appears within a few days of life. Neutropenia worsens during the very first days of life and persists until 20-50 days in spite of the disappearance of detectable antibody in the infant's serum. We report a case of ANN in female neonate who was admitted on the 5th day of life due to poor oral intake. The diagnosis was made by indirect immunofluorescence with fluorescein-tagged antihuman globulin reagent. The patient was treated successfully with systematic intravenous antibiotics and highdose intravenous immunoglobulin (IVIG).
