A Case of Citrullinemia Controlled by Diet and Arginine.
- Author:
Eun Young JEONG
1
;
Seong Sook JEON
;
Son Sang SEO
Author Information
1. Department of Pediatrics, Cytogenetics Laboratory, Il Sin Christian Hospital, Pusan, Korea.
- Publication Type:Case Report
- Keywords:
Citrullinemia;
Hyperammonemia;
Arginine
- MeSH:
Arginine*;
Citrulline;
Citrullinemia*;
Coma;
Diet*;
Humans;
Hyperammonemia;
Lethargy;
Ligases;
Male;
Metabolism;
Milk;
Seizures;
Sodium Benzoate;
Urea;
Vomiting;
Weaning
- From:Journal of the Korean Society of Neonatology
1999;6(2):280-280
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Citrullinemia is an inborn error of urea cycle metabolism caused by deficiency of arginosuccinate synthetase. It is characterized by hyperammonemia and high citrulline level in serum, CSF and urine. The clinical symptoms include vomiting, lethargy, seizure, coma and ultimately death if hyperammonemia is not controlled. We report a case of 9- day old male with citrullinemia who was initially treated with sodium benzoate during acute stage followed by gradual weaning to discontinuation. Hyperammonemia was well controlled by low protein milk diet and arginine.
