Change in the Prevalences and Risk Factors of Atrophic Gastritis and Intestinal Metaplasia in Korea: Multicenter Clinical Trials
10.7704/kjhugr.2018.18.4.247
- Author:
Young Jae HWANG
1
;
Nayoung KIM
;
Sung Eun KIM
;
Gwang Ho BAIK
;
Ju Yup LEE
;
Kyung Sik PARK
;
Young Eun JOO
;
Dae Seong MYUNG
;
Hyeon Ju KIM
;
Hyun Joo SONG
;
Heung Up KIM
;
Kwangwoo NAM
;
Jeong Eun SHIN
;
Hyun Jin KIM
;
Gwang Ha KIM
;
Jongchan LEE
;
Seon Hee LIM
;
Geom Seog SEO
;
Suck Chei CHOI
Author Information
1. Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. nayoungkim49@empas.com
- Publication Type:Multicenter Study
- Keywords:
Atrophic gastritis;
Helicobacter pylori;
Metaplasia;
Prevalence;
Risk factors
- MeSH:
Diet;
Fasting;
Gastritis, Atrophic;
Glucose;
Helicobacter pylori;
Humans;
Immunoglobulin G;
Korea;
Male;
Metaplasia;
Multivariate Analysis;
Prevalence;
Risk Factors;
Seroepidemiologic Studies;
Stomach Neoplasms
- From:The Korean Journal of Helicobacter and Upper Gastrointestinal Research
2018;18(4):247-257
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The aim of this study was to analyze the trend of the prevalences of atrophic gastritis (AG) and intestinal metaplasia (IM) from 2011 to 2016~2017 in Korea. And, the risk factors of AG and IM were compared between 2011 and 2016~2017. MATERIALS AND METHODS: A total of 4,023 subjects in 2011 and 2,506 subjects in 2016~2017 were enrolled. AG and IM were diagnosed on the basis of endoscopic findings. Multivariate analysis was performed for risk factors of AG and IM. Seventeen factors were analyzed. RESULTS: The seroprevalence of Helicobacter pylori decreased from 2011 (59.8%; 2,407/4,023) to 2016~2017 (51.6%; 1,293/2,506; P < 0.001). The prevalence of AG decreased from 2011 to 2016~2017 (P=0.018), but that of IM increased (P < 0.001). The risk factors of AG in 2011 were male sex, old age, H. pylori immuoglobulin G (IgG) positivity, family history of gastric cancer (GC), and high-salt diet. For IM in 2011, the risk factors were male sex, old age, H. pylori IgG positivity, and family history of GC. Risk factors of AG in 2016~2017 were old age, H. pylori IgG positivity, and country of residence. For IM in 2016~2017, the risk factors were male sex, old age, family history of GC, high fasting glucose level (≥126 mg/dL), H. pylori IgG positivity, and low income level. CONCLUSIONS: The difference in prevalence trends of AG and IM between 2016~2017 and 2011 could be the result of the different risk factors of AG and IM, such as decreased prevalence of H. pylori infection.
