Methimazole-Induced Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis in the Peripheral Nerves
10.11106/ijt.2018.11.2.176
- Author:
Mi Il KANG
1
;
Dohee KIM
Author Information
1. Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea. dh9070@dankook.ac.kr
- Publication Type:Case Report
- Keywords:
ANCA-associated vasculitis;
Antithyroid agents;
Graves' disease;
Methimazole
- MeSH:
Aged;
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis;
Antibodies, Antineutrophil Cytoplasmic;
Antithyroid Agents;
Female;
Graves Disease;
Humans;
Kidney;
Lower Extremity;
Methimazole;
Peripheral Nerves;
Peripheral Nervous System;
Prognosis;
Propylthiouracil;
Skin;
Vasculitis
- From:International Journal of Thyroidology
2018;11(2):176-181
- CountryRepublic of Korea
- Language:English
-
Abstract:
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis has been reported in Graves' disease patients treated with antithyroid drugs (ATDs), especially propylthiouracil. ATD-induced ANCA-associated vasculitis usually involved the kidneys followed by the respiratory organs and skin. The treatment of ANCA-associated vasculitis induced by ATDs is to stop ATD therapy immediately, which often leads to an overall good prognosis. We report a case of ANCA-associated vasculitis in the peripheral nerves of the lower extremities in a 66-year-old woman who was treated with methimazole (MMI) for Graves' disease. To our knowledge, this is the third case of peripheral nervous system (PNS) involvement of ATD-induced vasculitis and the first case of PNS vasculitis associated with MMI.
