Diagnostic Performance of Shear Wave Elastography as Add-on Test in Thyroid Nodules: a Systematic Review and Meta-Analysis
10.11106/ijt.2018.11.1.31
- Author:
Sun young PARK
1
;
Ji Yang SONG
;
Min Jin LEE
;
Kyung Min LEE
;
Mi Hye JEON
;
Ryeo Jin KO
;
Seok Hyun KIM
;
Bong Joo KANG
Author Information
1. Division of New Health Technology Assessment, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea. lionmain@catholic.ac.kr
- Publication Type:Meta-Analysis
- Keywords:
Thyroid nodule;
Shear wave elastography;
Diagnostic performance;
Effectiveness
- MeSH:
Acoustics;
Biopsy;
Diagnosis, Differential;
Elasticity Imaging Techniques;
Population Characteristics;
Sensitivity and Specificity;
Thyroid Gland;
Thyroid Nodule;
Ultrasonography
- From:International Journal of Thyroidology
2018;11(1):31-40
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: The diagnostic performance of shear wave elastography (SWE) combined with ultrasound (US) in the differential diagnosis of thyroid nodules was evaluated. MATERIALS AND METHODS: 459 articles were collected using KoreaMed, Ovid-MEDLINE, Ovid-EMBASE, and Cochrane Library. The searching words were ‘{(elastography and shear).mp. OR SWE.mp. OR acoustic radiation force impulse.mp. OR ARFI.mp. OR acuson.mp. OR aixplorer.mp.}’. Two authors independently performed article selection and evaluation of the quality of studies with Scottish Intercollegiate Guidelines Network tool. RESULTS: 2582 specimens (thyroid nodules) from 11 studies selected were included in this review. Combined use of US and SWE was reported higher specificity in five literatures, lower specificity in five studies, and no changes in 1 study when compared to US. We performed meta-analysis using data from 10 studies. The pooled sensitivity and specificity of US and SWE group for the differential diagnosis of benign and malignant nodules were 0.91 (I2=83.4%), 0.73 (I2=95.9%). The pooled sensitivity and specificity of US alone group were 0.88 (I2=93.2%), 0.71 (I2=92.7%). CONCLUSION: SWE is not effective in the differential diagnosis of thyroid nodules to minimize unnecessary biopsy of nodules. The included studies showed significant heterogeneity of results.
