Change of Heart Rate Variability in Depressive Disorder after Physical or Psychological Stress
10.14401/KASMED.2018.25.1.15
- Author:
Jong Hwa LEE
1
;
Jaehak YU
;
Seung Ho RYU
;
Ji Hyeon HA
;
Hong Jun JEON
;
Doo Heum PARK
Author Information
1. Department of Neuropsychiatry, Konkuk University Medical Center, Seoul, Korea. dhpark@kuh.ac.kr
- Publication Type:Original Article
- Keywords:
Autonomic nervous system;
Depressive disorder;
Heart rate variability;
Stress response
- MeSH:
Anxiety;
Autonomic Nervous System;
Depression;
Depressive Disorder;
Equipment and Supplies;
Heart Rate;
Heart;
Humans;
Posture;
Stress, Psychological
- From:Sleep Medicine and Psychophysiology
2018;25(1):15-20
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was designed to assess the change of heart rate variability (HRV) at resting, upright, and psychological stress states in depressive disorder patients. METHODS: HRV was measured at resting, upright, and psychological stress states in 62 depressive disorder patients. We used visual analogue scale (VAS) score to assess tension and stress severity. Beck depression inventory (BDI) and state trait anxiety inventories I and II (STAI-I and II) were used to assess depression and anxiety severity, respectively. Differences between HRV indices and VAS score were evaluated using paired t-tests. Gender difference analysis was conducted with ANCOVA. RESULTS: SDNN (standard deviation of normal to normal intervals), LF/HF (low frequency/high frequency), and VLF (very low frequency) were significantly increased, while NN50 and pNN50 were significantly decreased in the upright position compared to resting state. SDNN, RMSSD (root mean square of the differences of successive normal to normal intervals), and VLF were significantly increased, while pNN50 was significantly decreased in the psychological stress state compared to resting state. SDNN, NN50, and pNN50 were significantly lower in an upright position compared to a state of psychological stress, and LF, HF, and LF/HF showed no significant differences CONCLUSION: The LF/HF ratio was significantly increased after physical stress in depressive disorder. However, the LF/HF ratio was not significantly increased after psychological stress, and the change in LF/HF ratio after physical stress and psychological stress did not significantly differ from each other. Significant increase in SDNN, NN50, and pNN50 in an upright posture compared to psychological stress suggests that depressive patients react more sensitively to physical stress than psychological stress.
