Prescribing Pattern of Clozapine and Clinical Factors associated with Discontinuation of Clozapine
10.16946/kjsr.2019.22.1.1
- Author:
Shi Hyun KANG
1
;
Hey Won LEE
Author Information
1. Department of Adult Psychiatry, National Center for Mental Health, Seoul, Korea. drshe@hanmail.net
- Publication Type:Original Article
- Keywords:
Clozapine;
Antipsychotics;
Prescribing pattern;
Discontinuation;
Side effect
- MeSH:
Antipsychotic Agents;
Clozapine;
Humans;
Lost to Follow-Up;
Medical Records;
Polypharmacy;
Retrospective Studies;
Schizophrenia
- From:Korean Journal of Schizophrenia Research
2019;22(1):1-7
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Clozapine is the drug of choice in treatment-resistant schizophrenia. However, its use is often delayed and a significant proportion of clozapine treated patients fails to respond and experience potentially dangerous side-effects. The aim of this retrospective study was to describe the clinical characteristics of patients started on clozapine and the rate and reason of discontinuation of clozapine. METHODS: Medical records of 83 patients started on clozapine during the period of 2012–2016 were reviewed. RESULTS: Clozapine started on patients in chronic phase; the mean age of start was 38.1 years old and the mean number of psychiatric admission was 6.5. A majority (80.7%) of the patients had been subjected to antipsychotic polypharmacy prior to clozapine and most (61.5%) of them were being treated with polypharmacy including clozapine. Overall, 39 (47.0%) subjects had continued clozapine whereas 15 (18.1%) discontinued it; 29 (34.9%) were lost to follow-up. The most common reason for discontinuation was side-effects (n=13) including six life-threatening cases, most of which occurred within 6 months of its start. CONCLUSION: This study demonstrated that there is some evidence of delays to clozapine use, high rates of polypharmacy and significant rate of discontinuation during the early phase of clozapine treatment.
