Association between a Genetic Variant of CACNA1C and the Risk of Schizophrenia and Bipolar I Disorder Across Diagnostic Boundaries
10.16946/kjsr.2018.21.2.43
- Author:
Bora LEE
1
;
Ji Hyun BAEK
;
Eun Young CHO
;
So Yung YANG
;
Yoo Jin CHOI
;
Yu Sang LEE
;
Kyooseob HA
;
Kyung Sue HONG
Author Information
1. Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea. hongks@skku.edu
- Publication Type:Original Article
- Keywords:
CACNA1C;
Schizophrenia;
Bipolar disorder;
SNPs;
Genetic association study
- MeSH:
Bipolar Disorder;
Calcium Channels;
Genetic Association Studies;
Genome-Wide Association Study;
Humans;
Logistic Models;
Models, Genetic;
Phenotype;
Polymorphism, Single Nucleotide;
Schizophrenia
- From:Korean Journal of Schizophrenia Research
2018;21(2):43-50
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Genome-wide association studies (GWASs) and meta-analyses indicate that single-nucleotide polymorphisms (SNPs) in the a-1C subunit of the L-type voltage-dependent calcium channel (CACNA1C) gene increase the risk for schizophrenia and bipolar disorders (BDs). We investigated the association between the genetic variants on CACNA1C and schizophrenia and/or BDs in the Korean population. METHODS: A total of 582 patients with schizophrenia, 336 patients with BDs consisting of 179 bipolar I disorder (BD-I) and 157 bipolar II disorder (BD-II), and 502 healthy controls were recruited. Based on previous results from other populations, three SNPs (rs10848635, rs1006737, and rs4765905) were selected and genotype-wise association was evaluated using logistic regression analysis under additive, dominant and recessive genetic models. RESULTS: rs10848635 showed a significant association with schizophrenia (p=0.010), the combined schizophrenia and BD group (p=0.018), and the combined schizophrenia and BD-I group (p=0.011). The best fit model was dominant model for all of these phenotypes. The association remained significant after correction for multiple testing in schizophrenia and the combined schizophrenia and BD-I group. CONCLUSION: We identified a possible role of CACNA1C in the common susceptibility of schizophrenia and BD-I. However no association trend was observed for BD-II. Further efforts are needed to identify a specific phenotype associated with this gene crossing the current diagnostic categories.
