Association between Cognitive Function, Behavioral and Psychological Symptoms of Dementia and White Matter Hyperintensities in Patients with Alzheimer's Disease and Mild Cognitive Impairment
10.22722/KJPM.2018.26.2.119
- Author:
Ji Woong KWON
1
;
Hyun KIM
;
Kang Joon LEE
Author Information
1. Department of Psychiatry, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. lkj@paik.ac.kr
- Publication Type:Original Article
- Keywords:
Alzheimer's disease;
Mild cognitive impairment;
White matter hyperintensity;
Behavioral Psychological symptoms of dementia (BPSD)
- MeSH:
Aged;
Alzheimer Disease;
Brain;
Cognition;
Dementia;
Executive Function;
Humans;
Magnetic Resonance Imaging;
Mild Cognitive Impairment;
Retrospective Studies;
Weights and Measures;
White Matter
- From:Korean Journal of Psychosomatic Medicine
2018;26(2):119-126
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aim of this study is to investigate correlation between degree of white matter hyperintensities (WMH) and neurocognitive function along with behavioral and psychological symptoms of dementia (BPSD) in Korean patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). METHODS: Participants were 115 elderly subjects diagnosed with Alzheimer's disease or mild cognitive impairment in this retrospective study. WMH in brain MRI were rated with standardized visual rating scales (Fazekas scales) and the subjects were divided into two groups according to Fazekas scale. Cognitive function was evaluated with Korean version of the consortium to establish a registry for Alzheimer's Disease (CERAD-K), and BPSD was evaluated with Korean neuropsychiatric inventory (K-NPI). Independent t-test was performed to analyze the relationship between the degree of WMH and neurocognitive functions & BPSD. RESULTS: Especially, the group with high severity of WMH showed significantly lower language fluency (p < 0.05). In addition, the group with high severity of WMH showed significantly higher score in K-NPI. CONCLUSIONS: There was a significant association between WMH and neurocognitive test related with executive function. Moreover, WMH seems to affect BPSD severity. Evaluation of WMH would provide useful information in clinical settings.
