A Case of Clozapine-induced Corneal and Lenticular Pigmentation
10.3341/jkos.2019.60.3.276
- Author:
Ji Seon AN
1
;
Young Mi LEE
;
Joo Young KWAG
;
Joo HYUN
;
Jin Seok CHOI
;
Kyu Hong PAK
;
Sung Kun CHUNG
Author Information
1. Saevit Eye Hospital, Goyang, Korea. eyekun@gmail.com
- Publication Type:Case Report
- Keywords:
Clozapine;
Corneal pigmentation;
Lenticular pigmentation
- MeSH:
Clozapine;
Cornea;
Endothelium;
Humans;
Lorazepam;
Male;
Middle Aged;
Pigmentation;
Schizophrenia;
Slit Lamp
- From:Journal of the Korean Ophthalmological Society
2019;60(3):276-279
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report a case of corneal and lenticular pigmentation after prolonged clozapine therapy. CASE SUMMARY: A 56-year-old male visited our hospital with a progressive decline in vision that affected both eyes. He had a history of schizophrenia. He was being treated with 200 mg clozapine and 1 mg lorazepam daily, and had been treated with clozapine for 5 years. At the first visit, his best-corrected-visual acuity was 20/32 in both eyes. Slit lamp examination of the corneas showed bright, fine, grayish-brown deposits on the endothelium, and on dilation, bilateral central stellate opacity of the anterior portion of the lens capsule was revealed. CONCLUSIONS: Clozapine may induce corneal and lenticular pigmentation and thus may lead to a decline in vision. Patients on long-term clozapine therapy should be considered for regular ophthalmic review.
