Poorly Differentiated Neuroendocrine Carcinoma of the Eyelid
10.3341/jkos.2018.59.9.861
- Author:
Kyuyeon CHO
1
;
Jeong Hee KIM
;
Dong Cheol LEE
;
Yeon Lim SUH
;
Kyung In WOO
;
Yoon Duck KIM
Author Information
1. Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ydkimoph@skku.edu
- Publication Type:Case Report
- Keywords:
Eyelid;
Merkel cell carcinoma;
Poorly differentiated neuroendocrine carcinoma;
Small cell carcinoma;
Small cell neuroendocrine carcinoma
- MeSH:
Aged;
Carcinoma, Merkel Cell;
Carcinoma, Neuroendocrine;
Carcinoma, Small Cell;
Diagnosis, Differential;
Eyelids;
Frozen Sections;
Fungi;
Humans;
Keratin-20;
Male;
Synaptophysin;
Thyroid Gland
- From:Journal of the Korean Ophthalmological Society
2018;59(9):861-866
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To report a case of poorly differentiated neuroendocrine carcinoma of the eyelid. CASE SUMMARY: A 70-year-old male presented with a 5-month history of a right upper eyelid mass. The mass appeared as 1.2 × 1.2 cm on the right upper eyelid. A mass excision was performed under frozen section control. The tumor was completely excised with a safety margin clearance and an upper eyelid reconstruction was performed. Histopathological examination revealed a tumor composed of small atypical cells which showed a high nuclear/cytoplasm ratio, nuclear molding, and increased mitotic activity. Immunohistochemical examination revealed positive reactivity for Ki-67, synaptophysin, CD56, and negative reactivity for chromogranin, cytokeratin 20, and thyroid transcription factor-1. CONCLUSIONS: Primary neuroendocrine carcinoma of the eyelid is extremely rare, but the tumor has high malignancy and readily metastasizes. Poorly differentiated neuroendocrine carcinoma should be considered in the differential diagnosis of a rapidly growing eyelid mass.
