Long-term Results of Taking Anti-oxidant Nutritional Supplement in Intermediate Age-related Macular Degeneration
10.3341/jkos.2018.59.12.1152
- Author:
Seul Ki BANG
1
;
Eung Suk KIM
;
Jong Woo KIM
;
Jae Pil SHIN
;
Ji Eun LEE
;
Hyeong Gon YU
;
Kuhl HUH
;
Seung Young YU
Author Information
1. Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Korea. syyu@khu.ac.kr
- Publication Type:Multicenter Study
- Keywords:
Age-Related Eye Disease Study (AREDS)-2 formula;
Contrast sensitivity;
Drusen volume;
Intermediate age-related macular degeneration (AMD)
- MeSH:
Contrast Sensitivity;
Eye Diseases;
Humans;
Lutein;
Macular Degeneration;
Patient Satisfaction;
Prospective Studies;
Retinaldehyde;
Tomography, Optical Coherence;
Visual Acuity;
Zeaxanthins
- From:Journal of the Korean Ophthalmological Society
2018;59(12):1152-1159
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We prospectively investigated clinical changes and long-term outcomes after administration of the drugs recommended by the Age-Related Eye Disease Study-2 to patients with intermediate age-related macular degeneration (AMD). METHODS: This prospective multicenter study enrolled 79 eyes of 55 patients taking lutein and zeaxanthin. The primary endpoint was contrast sensitivity; this was checked every 12 months for a total of 36 months after treatment commenced. The secondary endpoints were visual acuity, central macular thickness, and drusen volume; the latter two parameters were assessed using spectral domain optical coherence tomography. RESULTS: The mean patient age was 72.46 ± 7.16 years. Contrast sensitivity gradually improved at both three and six cycles per degree. The corrected visual acuity was 0.13 ± 0.14 logMAR and did not change significantly over the 36 months. Neither the central macular thickness nor drusen volume changed significantly. CONCLUSIONS: Contrast sensitivity markedly improved after treatment, improving vision and patient satisfaction. Visual acuity, central retinal thickness, and drusen volume did not deteriorate. Therefore, progression of AMD and visual function deterioration were halted.
