Whole Exome Sequencing in the Accurate Diagnosis of Bilateral Breast Cancer: a Case Study
- Author:
Xiaoling LI
1
;
Mei YANG
;
Qiangzu ZHANG
;
Yanhui FAN
;
Teng ZHU
;
Fulong CHEN
;
Kun WANG
Author Information
- Publication Type:Case Report
- Keywords: Breast neoplasms; Differential diagnosis; Neoplasm metastasis; Whole exome sequencing
- MeSH: Asian Continental Ancestry Group; Breast Neoplasms; Breast; Diagnosis; Diagnosis, Differential; Exome; Female; Genome; Genomics; Humans; Middle Aged; Neoplasm Metastasis; Prognosis
- From:Journal of Breast Cancer 2019;22(1):131-140
- CountryRepublic of Korea
- Language:English
- Abstract: When faced with a case of bilateral breast cancer (BBC), understanding how to differentiate bilateral primary breast cancer from contralateral metastatic breast cancer is essential for treatment, but clear identification criteria have not been established to date. Diverse events play different roles in the therapy and prognosis of BBC; hence, it is of great significance to detect a more comprehensive and convincing technique to make an accurate differential diagnosis. We report a rare case of synchronous BBC in a 61-year-old Chinese woman. Based on her clinical and pathological features and the use of whole exome sequencing and cancer genome analysis, we concluded that the patient developed contralateral metastatic breast cancer which metastasized from left to right. Therefore, together with clinical, pathological and cancer genomics information, we could precisely define the origin and evolution of BBC.
