Cyclic Neutropenia with ELANE Gene Mutation in 3 Generations of Kindred
- VernacularTitle:3世代でELANE遺伝子変異が同定された周期性好中球減少症の男児例
- Author:
Takanori ISHII
1
;
Rohi TEI
2
;
Satoshi YAMADA
1
;
Minoru OKAZAKI
1
Author Information
- From:Journal of the Japanese Association of Rural Medicine 2019;67(5):596-
- CountryJapan
- Language:Japanese
- Abstract: We report the case of a 3-year-old boy with a history of repeated neutropenia and infection along with a significant family medical history. The diagnosis was cyclic neutropenia based on genetic testing. He had experienced frequent repeated episodes of fever since age 8 months, and he was found to have neutropenia when hospitalized due to acute otitis media at age 13 months. We obtained serial data of complete blood cell counts for 6 weeks when he was 3 years and 4 months old, which confirmed a cyclic increase and decrease in the number of neutrophils. ELANE gene testing was performed after obtaining written informed consent from the parents. A missense mutation was identified. At the parents’ request, we ran further testing and identified the same mutation in the father and paternal grandmother. Thus, 3 generations of kindred had the ELANE gene mutation. Because of repeated infections, prophylactic sulfamethoxazole trimethoprim was started from age 3 years and 10 months, resulting in a considerable decrease in the frequency of infections. Since age 4 years and 11 months, cyclic neutrophil over about 3 weeks has persisted, but there have been no serious infections requiring hospitalization.
