Relationship between urinary cadmium and type 2 diabetes mellitus in adults.
10.3760/cma.j.issn.0254-6450.2019.02.016
- Author:
L J LEI
1
;
J Y GUO
1
;
X J SHI
1
;
H KANG
1
;
T WANG
2
;
Z ZHANG
1
;
Y Y GAO
1
Author Information
1. Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
2. Department of Health Statistics, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.
- Publication Type:Journal Article
- Keywords:
Cadmium;
Diabetes Mellitus, type 2;
Influence factors;
Multiple-factors analysis
- MeSH:
Adult;
Cadmium/urine*;
Case-Control Studies;
China/epidemiology*;
Creatinine;
Diabetes Mellitus, Type 2/epidemiology*;
Female;
Humans;
Risk Factors;
Socioeconomic Factors
- From:
Chinese Journal of Epidemiology
2019;40(2):207-211
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the relationship between environmental factors as urinary cadmium and type 2 diabetes mellitus (DM) in adults. Methods: Case-control study was adopted, including 166 cases and 427 controls. General characteristics of the subjects were collected by a structured questionnaire. FPG, biochemical indexes and urinary cadmium (UCd) were detected respectively, while UCd was corrected with creatinine. Unconditioned logistic regression model was applied to analyze the relationship between UCd and DM. Results: Levels of UCd appeared higher in cases with the following characteristics as: having primary school education (P=0.016), being female (P=0.013), being non-smokers (P=0.014) or non-alcoholic (P=0.025), and with BMI>25.00 kg/m(2) (P=0.040, P=0.025) than those appeared in the control group. Same results were shown in the 60-69 years (P=0.024) old group. Data from the unconditional logistic regression analysis showed that family history of DM (OR=3.19, 95%CI: 1.45-7.03), education status (OR=1.50,95%CI: 1.08-2.08) and UCd (OR=1.61, 95%CI: 1.08-2.41) were influencing factors on DM. Conclusion: A close association between UCd and DM was noticed. UCd appeared a risk factor on DM that called for setting up related prevention program to reduce the exposure of Cd and to control the risk on DM.
