Introduction on 'assessing the risk of bias of individual studies' in systematic review of health-care intervention programs revised by the Agency for Healthcare Research and Quality.
10.3760/cma.j.issn.0254-6450.2019.01.021
- Author:
J C YANG
1
;
Z R YANG
2
;
S Q YU
1
;
S Y ZHAN
3
,
4
;
F SUN
3
,
4
Author Information
1. Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China.
2. Primary Care Unit, University of Cambridge, Cambridge CB1 8RN, UK.
3. Department of Epidemiology and Biostatistics, Peking University School of Public Health, Beijing 100191, China
4. Center of Evidence-based Medicine and Clinical Research, Peking University, Beijing 100191, China.
- Publication Type:Journal Article
- Keywords:
Common study designs;
Intervention study;
Risk of bias;
Systematic review;
Tool for assessment
- MeSH:
Bias;
Evidence-Based Medicine/standards*;
Health Services Research;
Systematic Reviews as Topic
- From:
Chinese Journal of Epidemiology
2019;40(1):106-111
- CountryChina
- Language:Chinese
-
Abstract:
This paper summarizes the Risk of Bias of Individual Studies in Systematic Reviews of Health Care Interventions revised by the Agency for Healthcare Research and Quality (AHRQ) and introduces how to use Revman software make risk of bias graph or risk of bias summary. AHRQ tool can be used to evaluate following study designs: RCTs, cohort study, case-control study (including nested case-control), case series study and cross-sectional study. The tool evaluates the risk of bias of individual studies from selection bias, performance bias, attrition bias, detection bias and reporting bias. Each of the bias domains contains different items, and each item is available for the assessment of one or more study designs. It is worth noting that the appropriate items should be selected for evaluation different study designs instead of using all items to directly assess the risk of bias. AHRQ tool can be used to evaluate risk of bias individual studies when systematic reviews of health care interventions is including different study designs. Moreover, the tool items are relatively easy to understand and the assessment process is not complicated. AHRQ recommends the use of high, medium and low risk classification methods to assess the overall risk of bias of individual studies. However, AHRQ gives no recommendations on how to determine the overall bias grade. It is expected that future research will give corresponding recommendations.
