Human leukocyte antigen polymorphism of HIV infected persons without disease progress for long-term in Henan province, 2011-2016.
10.3760/cma.j.issn.0254-6450.2019.01.018
- VernacularTitle:洞南省2011-2016年HIV感染长期不进展者人类白细胞抗原基因多态性分析
- Author:
X J XUE
1
;
J Z YAN
1
;
D CHENG
2
;
C H LIU
1
;
J LIU
1
;
Z LIU
3
;
S A TIAN
1
;
D Y SUN
1
;
B W ZHANG
3
;
Z WANG
1
Author Information
1. Department of AIDS/STD Control and Prevention, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
2. Xinxiang Prefecture Center for Disease Control and Prevention, Xinxiang 453000, China.
3. Henan Red Cross Blood Center, Zhengzhou 450016, China.
- Publication Type:Journal Article
- Keywords:
Genetic polymorphism;
HIV;
Human leukocyte antigen;
Long-term non-progressor
- MeSH:
Adult;
Alleles;
Asian People/genetics*;
China;
Disease Progression;
Female;
HIV;
HIV Infections/virology*;
HIV-1/immunology*;
HLA-B Antigens/genetics*;
Humans;
Middle Aged;
Polymorphism, Genetic;
Retrospective Studies;
Viral Load
- From:
Chinese Journal of Epidemiology
2019;40(1):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the disease progression and human leukocyte antigen (HLA) gene polymorphism of HIV-infected persons without disease progress for long term, also known as long-term non-progressors (LTNPs), in Henan province. Methods: A retrospective study was conducted in 48 LTNPs with complete detection and follow-up information during 2011-2016 in Henan. Changes of CD(4)(+)T cells counts (CD(4)) and viral load (VL) during follow-up period were discussed. Polymerase chain reaction-sequence-specific oligonucleotide probe (PCR-SSOP) was used for the analyses of HLA-A, HLA-B and HLA-DRB1 alleles between LTNPs and healthy controls. Results: From 2011 to 2016, forty-eight LTNPs showed a decrease of the quartile (P(25)-P(75)) of CD(4) from 601.00 (488.50-708.72)/μl to 494.00 (367.00-672.00)/μl, and the difference was significant (P<0.05). The increase of the quartile (P(25)-P(75)) of log(10)VL from 3.40 (2.87-3.97) to 3.48 (2.60-4.37), but the difference was not significant (P>0.05). HLA polymorphism analysis revealed that HLA-B*13:02 and HLA-B*40:06 were more common in LTNPs (P<0.05), while HLA-B*46:01 and HLA-DRB1*09:01 were more common in healthy controls (P<0.05). Conclusions: The CD(4) of LTNPs in Henan showed a downward trend year by year. HLA-B*13:02 and B*40:06 might be associated with delayed disease progression for HIV infected persons in Henan.
