HIV-1 gene subtypes among newly reported HIV/AIDS cases in two border areas of Yunnan province.
10.3760/cma.j.issn.0254-6450.2018.12.015
- Author:
T WEI
1
;
C J YANG
2
;
M CHEN
2
;
M H JIA
2
;
Y L MA
2
;
H B LUO
2
;
L LU
3
,
4
Author Information
1. School of Public Health, Kunming Medical University, Kunming 650500, China.
2. Yunnan Provincial Center for Disease Control and Prevention, Kunming 650022, China.
3. School of Public Health, Kunming Medical University, Kunming 650500, China
4. Health and Family Planning Commission of Yunnan Province, Kunming 650200, China.
- Publication Type:Journal Article
- Keywords:
Border areas;
Gene subtypes;
HIV/AIDS cases
- MeSH:
Adolescent;
Adult;
China/epidemiology*;
Female;
Genotype;
HIV Infections/virology*;
HIV-1/genetics*;
Humans;
Male;
Middle Aged;
Myanmar/ethnology*;
Phylogeny;
RNA, Viral/genetics*;
Young Adult
- From:
Chinese Journal of Epidemiology
2018;39(12):1617-1620
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To explore the features of distribution on HIV-1 gene subtypes among newly reported HIV/AIDS cases in the border areas of Yunnan province. Methods: A total of 233 newly reported HIV/AIDS cases aged 18 or more were consecutively included in the border counties of Dehong Dai and Jingpo autonomous prefecture (Dehong prefecture), Honghe Hani and Yi autonomous prefecture (Honghe prefecture) of Yunnan province from November 2015 to October 2016. HIV-1 RNA was extracted with pol and env genes amplified. HIV-1 gene subtypes were determined through phylogenetic analysis. Results: A total of 146 out of 233 specimens were genotyped successfully. HIV-1 was found to have had 8 gene subtypes in Dehong prefecture, with the unique recombinant forms (URFs) as the predominant (52.8%, 57/108) type, including 56.8% (21/37) of the cases with Chinese ethnicity and another 50.7% (36/71) were Myanmar citizens. Four HIV-1 gene subtypes were detected in Honghe prefecture, with CRF01_AE as predominant (71.1%, 27/38), including 81.0% (17/21) Vietnamese and 58.8% (10/17) Chinese. Differences on the distribution of HIV-1 gene subtypes were seen statistically significant between Dehong prefecture and Honghe prefecture (χ(2)=61.072, P<0.001). Conclusions: The distribution of HIV-1 gene subtypes showed big difference in the two border areas of Yunnan province, suggesting that both Chinese or non- Chinese citizens living in the area should be taken good care of, in terms of HIV/AIDS prevention and control.
