Survey on a norovirus-borne outbreak caused by GⅡ.4 Sydney 2012 variant in a university of Guangzhou, 2017.
10.3760/cma.j.issn.0254-6450.2018.12.007
- VernacularTitle:广州市2017年某高校诺如病毒GⅡ.4Sydney2012变异株感染暴发调查
- Author:
M M MA
1
;
H WANG
1
;
J Y LU
1
;
D H WANG
1
;
Q ZENG
2
;
J M GENG
2
;
T G LI
1
;
Z B ZHANG
3
;
Z C YANG
3
Author Information
1. Department of Infectious Disease Prevention and Control, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
2. Department of Virology and Immunology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
3. Office of the Director, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.
- Publication Type:Journal Article
- Keywords:
Diarrhea;
Epidemiology;
Norovirus;
Outbreak
- MeSH:
Adolescent;
Adult;
Caliciviridae Infections/epidemiology*;
Case-Control Studies;
China/epidemiology*;
Disease Outbreaks;
Female;
Foodborne Diseases/virology*;
Gastroenteritis/virology*;
Humans;
Male;
Norovirus/isolation & purification*;
Phylogeny;
Surveys and Questionnaires
- From:
Chinese Journal of Epidemiology
2018;39(12):1570-1575
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the epidemiological and molecular characteristics of a norovirus- borne outbreak caused by GⅡ.4 Sydney 2012 in a university of Guangzhou to provide evidence for the prevention and control strategy on norovirus-caused epidemics. Methods: A self-designed questionnaire was used to collect clinical information from the patients as well as other data related to the epidemic. Pathogen detections were performed through anal swab specimens from the patients, kitchen workers and samples from the environment. Positive samples were further sequenced for phylogenetic analysis. A case-control study was employed to identify the risk factors related to this outbreak. Results: A total of 226 cases of norovirus-borne infection were identified between September 17 and 21, 2017, including 223 students, with an attack rate of 0.73% (223/30 711), and 3 kitchen workers. Students staying in the A dormitory area had the highest attack rate (1.73%, 164/9 459). No clustering was found in different colleges or classes. Results from the case-control study revealed that people who ate at the canteen in A dormitory area during September 18 to 20 was at risk for the onset of illness (OR=10.75, 95%CI: 5.56-20.79). The highest risk was related to the dinner on September 18. Another significant risk factor (OR=3.65, 95%CI: 1.92-6.94) was close personal contact in the same room of the dorm. The 3 norovirus infected kitchen workers were all from the canteen in A dormitory area where the positive rate of norovirus identified in kitchen workers was 26.67% (12/45). Positive samples were sequenced and sub-typed with results showing that the GⅡ.4 Sydney 2012 variant and the nucleotide sequences of cases and kitchen workers were 100% identical. Conclusions: The outbreak was caused by norovirus GⅡ.4 Sydney 2012 variant at campus. Similar outbreaks had been seen since 2013, with the routes of transmission most likely due to food-borne or personal contact.
