A cohort study on the association between dynamics of thyroid volume and the changes of physical growth as well as the comparison of different thyroid volume indexes in school-aged children.
10.3760/cma.j.issn.0254-6450.2018.12.002
- VernacularTitle:学龄儿童甲状腺容积变化与体格发育变化的关联及不同甲状腺容积指数适用性的队列研究
- Author:
Y Y WANG
1
;
Alitengsaier NI GEDELI
;
C W FU
;
F JIANG
;
Q ZHAO
;
N WANG
;
Q W JIANG
Author Information
1. Key Laboratory of Public Health Safety, Ministry of Education, School of Public Health, Fudan University, Shanghai 200032, China.
- Publication Type:Journal Article
- Keywords:
Cohort study;
School-aged children;
Thyroid;
Volume
- MeSH:
Body Mass Index;
Body Weight;
Child;
China;
Cohort Studies;
Female;
Goiter;
Humans;
Iodine;
Male;
Organ Size;
Thyroid Gland/growth & development*
- From:
Chinese Journal of Epidemiology
2018;39(12):1544-1548
- CountryChina
- Language:Chinese
-
Abstract:
Objectives: To investigate the association between the dynamics of thyroid volume and the changes of physical growth in school-aged children as well as to compare the applicability of different thyroid volume indexes, so as to explore more reliable methods for the assessment of thyroid volume. Methods: In October 2012, a multi-stage cluster sampling method was used to select a primary school in Minhang district of Shanghai, Haimen city of Jiangsu province and Yuhuan city of Zhejiang province, respectively. In these areas, a total number of 784 students aged 8-10 years were enrolled in the cohort. Demographic data was collected, while height and weight were measured, with BMI and body surface area (BSA) were calculated. Thyroid volume was examined by B-ultrasonography. Height volume index (HVI), weight and height volume index (WHVI), BMI volume index (BMIV) and BSA volume index (BSAV) were all applied to correct the thyroid volume. All students were followed up, one year later. Results: A total of 769 students with complete data on thyroid volume and physical growth were enrolled, including 378 boys (49.16%) and 391 girls (50.84%). Thyroid volume showed an increase with age, while growth of thyroid volume reduced with the increase of age (P<0.001). The thyroid volume showed a correlation with the changes of physical growth. The growth of height appeared as the dominant influencing factor for thyroid volume growth in those aged 8 and 10 years (P<0.05), while the growth of weight, BMI and BSA were all influencing factors for thyroid volume on students aged 9 years (P<0.05). Conclusions: Thyroid volume in school-aged children was a factor not only associated with age but also with physical growth which had not been considered in the currently used criteria. The inclusion of items as iodine intake, age, physical growth into the thyroid volume indexes seemed to be more reliable, in practice. For the assessment of goiter, HVI for students aged 8 and 10 years and BMIV for students aged 9 years might serve as better indicators.
