Progress in research of influence of gene polymorphisms on immune response.
10.3760/cma.j.issn.0254-6450.2018.11.018
- Author:
J Q CAO
1
;
J X LI
2
;
Y Y WANG
1
;
F C ZHU
2
,
3
Author Information
1. School of Public Health, Nanjing Medical University, Nanjing 211166, China.
2. Department of Vaccine Clinical Evaluation, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
3. School of Public Health, Nanjing Medical University, Nanjing 211166, China
- Publication Type:Review
- Keywords:
Gene;
Immune response;
Vaccine
- MeSH:
Cytokines;
Genetic Variation/immunology*;
Humans;
Immune System;
Immunity/physiology*;
Immunity, Active/immunology*;
Immunogenetics;
Polymorphism, Genetic;
Vaccination;
Vaccines/immunology*
- From:
Chinese Journal of Epidemiology
2018;39(11):1515-1518
- CountryChina
- Language:Chinese
-
Abstract:
Genes play an important role in the immune system response, and different gene loci may result in different vaccine immune response rates. This review focuses on the correlation between gene polymorphisms and vaccine immune response in order to investigate the influence of gene polymorphisms on the immune response to vaccines. It discusses the effect of an individual's immune response after vaccination at genetic level and provides a scientific basis for individualized immune development strategies. It reveals that human leukocyte antigen genes, various cytokines and their receptor genes, and Toll-like receptor genes all affect the vaccine immune response.
