Fujian Tulou Family Cohort Study: study design and characteristics of participants and pedigrees in baseline investigation.
10.3760/cma.j.issn.0254-6450.2018.10.020
- Author:
H HUANG
1
;
Y YE
2
;
C L HUANG
3
;
W J GAO
1
;
M Y WANG
1
;
W Y LI
1
;
R ZHOU
1
;
C Q YU
1
;
J LYU
1
;
X L WU
3
;
X M HUANG
3
;
W H CAO
1
;
Y S YAN
2
;
T WU
1
;
L M LI
1
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.
2. Department of Local Diseases Control and Prevention, Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350001, China.
3. Department of Hygiene, Nanjing County Center for Disease Control and Prevention, Nanjing 363600, China.
- Publication Type:Journal Article
- Keywords:
Baseline survey;
Family cohort;
Fujian Tulou
- MeSH:
Adolescent;
Adult;
Aged;
China/epidemiology*;
Chronic Disease/ethnology*;
Cohort Studies;
Diabetes Mellitus/ethnology*;
Family Health;
Female;
Gene-Environment Interaction;
Genetic Predisposition to Disease/ethnology*;
Humans;
Hyperlipidemias/ethnology*;
Hypertension/ethnology*;
Male;
Middle Aged;
Pedigree;
Prospective Studies;
Risk Factors;
Surveys and Questionnaires
- From:
Chinese Journal of Epidemiology
2018;39(10):1402-1407
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To describe the study design, the characteristics of participants as well as the pedigrees included in the baseline survey of Fujian Tulou Family Cohort Study. Methods: Fujian Tulou Family Cohort Study was a prospective open cohort study with a biological sample bank. A baseline survey was conducted in Tulou areas of Nanjing county in Fujian province from 2015 to 2018, including questionnaire survey, physical and biochemical indicators examinations, and blood sample collection in adults aged ≥18 years. In addition, family relationship of the participants was also recorded. The pedigree information of the juveniles under 18 years old were also collected. Results: The baseline survey included 2 727 individuals in two clans, of whom 2 373 (87.0%) were adults, and 2 126 participants completed questionnaires, physical examinations and biochemical tests. The average age of the 2 126 participants was (57.9±13.3) years, with 39.4% being males. The current smoking rates in male and female participants were 41.2% and 2.1%, respectively. The corresponding rates of current alcohol consumption were 19.0% and 2.6%. For common chronic diseases, the prevalence rates were 51.3% for hypertension, 9.7% for diabetes and 26.7% for hyperlipemia according to the self-reported disease diagnoses, health examination results and biochemical examination results in class Ⅱ or Ⅲ hospitals. Based on the family relationship information and genealogical data, 710 pedigrees were finally identified, consisting of 5 087 family members. The numbers of five, four, three, and two generations pedigrees were 3, 88, 238 and 381, respectively. The pairs of the first to the fifth degree relatives were 12 039, 2 662, 1 511, 202 and 31, respectively. Conclusion: The establishment of Fujian Tulou Family Cohort provides valuable resources for exploring the genetic risk factors, environmental risk factors and gene-environment interactions contributing to the risk of common chronic diseases.
