Prevalence and associated risk factors on preterm birth, low birth weight, and small for gestational age among HIV-infected pregnant women in Hunan province, 2011-2017.
10.3760/cma.j.issn.0254-6450.2018.10.015
- VernacularTitle:湖南省2011-2017年孕产妇HIV感染者早产、低出生体重和小于胎龄儿发生率及其影响因素分析
- Author:
H X LI
1
;
J F ZHENG
2
;
G W HUANG
1
;
J XIAO
1
;
H WANG
3
;
M YANG
3
;
N FENG
4
Author Information
1. Department of Child Health Care, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, China.
2. Department of Emergency Medicine, Second Xiangya Hospital, Central South University, Changsha 410011, China.
3. Department of Maternal Health, Hunan Provincial Maternal and Child Health Care Hospital, Changsha 410008, China.
4. Department of Health Care, Shenzhen Nanshan Maternal and Child Health Care Hospital, Shenzhen 518067, China.
- Publication Type:Journal Article
- Keywords:
HIV infection;
Low birth weight;
Pregnant women;
Preterm birth;
Small for gestational age
- MeSH:
Adult;
Birth Weight;
Child;
China/epidemiology*;
Female;
Gestational Age;
HIV Infections/epidemiology*;
Humans;
Infant, Low Birth Weight;
Infant, Newborn;
Infant, Small for Gestational Age;
Pregnancy;
Pregnancy Complications, Infectious/virology*;
Premature Birth/etiology*;
Prevalence;
Retrospective Studies;
Risk Factors
- From:
Chinese Journal of Epidemiology
2018;39(10):1368-1374
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To describe the prevalence of preterm birth (PB), low birth weight (LBW), and small for gestational age (SGA) among HIV-infected pregnant women and to identify associated risk factors in Hunan province. Methods: This study appeared a retrospective one on HIV-infected pregnant women retrieved from Information System of Prevention of Mother-to-child Transmission of HIV management in Hunan province, between January 2011 and December 2017. Information regarding demographic characteristics, pregnancy, antiretroviral therapy (ART), husbands/partners' relevant situation and pregnancy outcomes, among these HIV-infected pregnant women were collected and analyzed. The incidence rates on PB, LBW and SGA were calculated. Multivariate logistic regression was used to analyze the associated risk factors. Results: A total of 780 HIV-infected pregnant women were enrolled. The prevalence rates on PB, LBW and SGA in HIV- infected pregnant women appeared as 7.9% (62/780), 9.9% (77/780) and 21.3% (166/780), respectively. Results from the multivariate logistic regression analysis showed that factors as pregnancy related diseases as moderate/severe anemia, hypertensive, initial time of ART <14 gestational weeks (compared to those women without ART during pregnancy) and husbands/partners' age >35 years old (compared to husbands/partners' age 26-30 years old) etc., were associated with an increased risk of PB with adjusted OR as 4.59 (95%CI: 1.51-13.95), 4.90 (95%CI: 1.56-15.46), 2.40 (95%CI: 1.26- 4.56) and 2.29 (95%CI: 1.21-4.36). For LBW, pregnancy moderate/severe anemia, pregnancy HBV infection and initial time of ART <14 gestational weeks were associated with an increased risk of LBW, with adjusted OR as 3.28 (95%CI: 1.13-9.54), 4.37 (95%CI: 1.42-13.44) and 2.68 (95%CI: 1.51-4.76), respectively. For SGA, pregnancy HBV infection and initial time of ART <14 gestational weeks were risk factors for SGA, with adjusted OR as 4.41 (95%CI: 1.43-13.63) and 2.67 (95%CI: 1.51-4.73), respectively. Conclusion: Preterm birth, LBW and SGA were common adverse pregnancy outcomes for HIV-infected pregnant women and were associated with factors as pregnancy complications, ART and husbands/partners' age.
