Abuse of diphenoxylate and related factors of forced drug abstainer in Gansu province.
10.3760/cma.j.issn.0254-6450.2018.09.015
- Author:
J J HUANG
1
;
Y M RONG
2
;
R C LI
1
;
Y L LI
1
;
Y X YANG
1
;
K F BAO
1
;
J H ZHANG
3
;
Y Q LIU
3
;
X Y DU
3
;
S ZHENG
1
;
Y N BAI
1
Author Information
1. Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou 730000, China.
2. Shandong Provincial Center for Adverse Drug Reaction Monitoring, Jinan 250014, China.
3. Gansu Provincial Center for Drugs and Medical Devices Adverse Reaction Monitoring, Lanzhou 730000, China.
- Publication Type:Journal Article
- Keywords:
Diphenoxylate;
Drug abuse;
Related factor
- MeSH:
Analgesics, Opioid/supply & distribution*;
Case-Control Studies;
China;
Diphenoxylate/supply & distribution*;
Humans;
Substance Withdrawal Syndrome;
Substance-Related Disorders/psychology*;
Surveys and Questionnaires
- From:
Chinese Journal of Epidemiology
2018;39(9):1222-1227
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the prevalence of diphenoxylate abuse and related factors of forced drug abstainer in Gansu province. Methods: By using a self-designed questionnaire, an epidemiologic investigation was carried out among 2 108 forced drug abstainer selected from the compulsory isolation detoxification center of Gansu province. A case-control study was conducted to analyze the factors related with diphenoxylate abuse. Results: The diphenoxylate abuse rate among forced drug abstainer in Gansu was 19.8% (406/2 046), ranking first in medical drug abuse. Multiple logistic regression analysis showed that factors as relieving withdrawal symptoms (OR=2.08, 95%CI: 1.01- 4.32), ways to obtain diphenoxylate (other ways: OR=1.00; regular clinic: OR=27.67, 95%CI: 2.64-289.82; friend: OR=0.01, 95%CI: 0.01-0.03), degree of euphoria (high: OR=1.00; medium: OR =3.36, 95%CI: 1.18-9.55; low: OR=26.16, 95%CI: 10.30-66.42), years of drug abuse (<5 years: OR=1.00; 10-15 years: OR=2.48, 95%CI: 1.02-6.04), abuse at home or in friend's house (OR=3.04, 95%CI: 1.08-8.68), abuse in car (OR=0.05, 95%CI: 0.00-0.68) and detoxification for the first time (OR=0.61, 95%CI: 0.43-0.86) were the possible influencing factors for diphenoxylate abuse. Conclusions: The prevalence of diphenoxylate abuse in forced drug abstainer in Gansu was relatively high. Reasons of abusing, the way to obtain diphenoxylate, whether using drug together with friends, degree of euphoria, years of abuse, abuse place and times for detoxification were related factors influencing the abuse of diphenoxylate.
