Prospective cohort study on the risks of pre-pregnancy overweight, excessive gestational weight gain on macrosomia.
10.3760/cma.j.issn.0254-6450.2018.08.013
- Author:
Z P ZHANG
1
;
L M CHU
1
;
S L CHU
1
;
M LU
2
;
L H SHEN
1
;
K CHEN
2
;
L F GU
1
;
H T WU
1
;
J SHEN
2
Author Information
1. Department of Obstetrics and Gynecology, Shanghai Pudong New Area Healthcare Hospital for Women and Children, Shanghai, 201206, China.
2. Key Laboratory of Reproduction Regulation of National Population and Family Planning Commission, Shanghai Institute of Planned Parenthood Research, Institute of Reproductive and Developmental Studies, Fudan University, Shanghai, 200032, China.
- Publication Type:Journal Article
- Keywords:
Excessive gestational weight gain;
Macrosomia;
Prepregnancy obesity;
Prepregnancy overweight;
Prospective cohort study
- MeSH:
Body Mass Index;
Cesarean Section/statistics & numerical data*;
China/epidemiology*;
Female;
Fetal Macrosomia/epidemiology*;
Humans;
Incidence;
Logistic Models;
Obesity/epidemiology*;
Overweight/epidemiology*;
Pregnancy;
Pregnancy Complications/epidemiology*;
Prospective Studies;
Weight Gain
- From:
Chinese Journal of Epidemiology
2018;39(8):1082-1085
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the risks of pre-pregnancy overweight, excessive gestational weight gain on macrosomia. Methods: We conducted one hospital-based cohort study, focusing on pregnant women from January 2015. All pregnant women attending to this hospital for maternal check-ups, were included in our cohort and followed to the time of delivery. Data related to general demographic characteristics, pregnancy and health status of those pregnant women, was collected and maternal pre-pregnant BMI and maternal weight gain were calculated. Logistic regression was used to explore the risk difference of pre-pregnancy BMI, excessive gestational weight gain on macrosomia. Results: The overall incidence of macrosomia in our cohort appeared as 6.6% (149/2 243). After adjusting the confounding factors including age and histories on pregnancy, pre-pregnancy overweight/obesity was associated with higher risks of macrosomia (OR=3.12, 95%CI: 1.35-7.22, P=0.008; OR=2.99, 95%CI: 1.17-7.63, P=0.022) when comparing to those with normal pre-pregnancy weight. Cesarean delivery and sex of the offspring were associated with higher risk of macrosomia, while excessive gestational weight gain showed no significant difference (OR=1.41, 95%CI: 0.96-2.09, P=0.084). Our data showed that Macrosomia was statistically associated with gestational weight gain (P=0.002). After controlling parameters as age, history of pregnancy and related complications of the pregnant women, results from the logistic regression showed that women with gestational inadequate weight gain having reduced risks to deliver macrosomia, when compared to those pregnant women with adequate weight gain (OR=0.52, 95%CI: 0.30-0.90, P=0.019). Conclusion: Pre-pregnancy overweight and obesity were on higher risks to macrosomia.
