Diagnostic and epidemiological features of the first two HIV-2 indigenous infections in Hunan province.
10.3760/cma.j.issn.0254-6450.2018.08.012
- Author:
J Y PENG
1
;
J ZHENG
1
;
J M HE
1
;
Y JIANG
1
;
D YAO
2
;
X CHEN
1
Author Information
1. Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China.
2. Changsha Center for Disease Control and Prevention, Changsha 410004, China.
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Epidemiological cases investigation;
HIV-2
- MeSH:
Adult;
Blotting, Western/methods*;
China;
HIV Antibodies/isolation & purification*;
HIV Infections/ethnology*;
HIV-2/immunology*;
Humans;
Sexual Behavior;
Sexual Partners;
Surveys and Questionnaires
- From:
Chinese Journal of Epidemiology
2018;39(8):1077-1081
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the diagnostic and epidemiological features of the first two HIV-2 indigenous cases in Hunan province. Methods: Blood samples from two individuals with "HIV antibody indeterminate" and HIV-2 specific band showed by HIV-1/2 western blotting method, were repeatedly collected and detected under HIV 1+2 strip immunoassay and PCR, in Changsha city, Hunan province, through March to November, 2017. An epidemiological survey was carried out at the same time. Results: Our findings showed that the two cases were sex partners, without histories of sexual contact with foreigners and the source of infection was unknown. Results from the HIV 1+2 antibody confirmation test showed that they were "HIV-2 antibody positive" . Through amplifying and sequencing the gag area of HIV-2 and BLAST, the similarity of HIV-2 strains presented as 98%. The results also showed that there were HIV-2 specific fragments in the two cases. Conclusion: HIV-2 indigenous cases had never been reported in China. These cases had brought new challenge on prevention, diagnosis and treatment of HIV/AIDS in China.
