Source tracing of the Yersinia pestis strains isolated from Heqing county, Yunnan province in 2017.
10.3760/cma.j.issn.0254-6450.2018.07.022
- Author:
L Y SHI
1
;
Y B DING
1
;
H L TAN
1
;
Y GUO
1
;
H P ZHANG
1
;
C J DUAN
1
;
W LI
2
;
P WANG
1
Author Information
1. Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Yunnan Collaborative Innovation Center of Public Health and Disease Control and Prevention, Yunnan Institute for Endemic Diseases Control and Prevention, Dali 671000, China.
2. State Key Laboratory for Communicable Diseases Control and Prevention, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
- Publication Type:Journal Article
- Keywords:
Heqing;
Multiple-locus variable-number tandem repeat analysis;
Plague
- MeSH:
Animals;
China/epidemiology*;
Epidemiological Monitoring;
Genotype;
Minisatellite Repeats;
Molecular Typing;
Plague/microbiology*;
Rodentia/microbiology*;
Yersinia pestis/pathogenicity*
- From:
Chinese Journal of Epidemiology
2018;39(7):983-987
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the genotype of the Yersinia (Y.) pestis strains isolated from Heqing county, Yunnan province in 2017 and provide evidence for the prevention and control of plague in this area. Methods: Ten Y. pestis strains isolated from Heqing were typed by the detections of different region (DFR) and clustered regularly interspaced short palindromic repeats (CRISPRs) as well as multiple-locus variable-number tandem repeat analysis (MLVA). And the results were compared with those of the 93 Y. pestis strains from the adjacent plague foci of Heqing obtained from the established database for clustering analysis. Results: The results showed that Heqing strains had the same type of DFR (Genomovar 05) and CRISPRs (Cluster Ca7, Type 22) with isolates from the plague focus in Lijiang. Heqing strains and Lijiang strains were in the same cluster in MST and only VNTR loci N2117 and M23 of Heqing strains were different from that of Lijiang strains. Conclusion: The Y. pestis strains isolated from Heqing in 2017 were highly homogenous with the strains isolated from wild rodents in plague focus in Lijiang, and Heqing plague might be the result of further southward spread of Lijiang plague.
