Analysis on 10 year survival of HIV/AIDS patients receiving antiretroviral therapy during 2003-2005 in Henan province.
10.3760/cma.j.issn.0254-6450.2018.07.019
- VernacularTitle:河南省2003-2005年HIV/AIDS抗病毒治疗随访10年生存状况分析
- Author:
Y SUN
1
;
Q X ZHAO
;
C F LI
;
X YANG
;
X ZHANG
;
C L LIU
;
Z Y CHEN
Author Information
1. Department of Infectious Disease. Zhengzhou 6th People's Hospital, Zhengzhou 450015, China.
- Publication Type:Journal Article
- Keywords:
Antiretroviral therapy;
HIV/AIDS;
Influencing factors;
Long-term;
Survival analysis
- MeSH:
Acquired Immunodeficiency Syndrome;
Adult;
Aged;
Antiretroviral Therapy, Highly Active;
CD4 Lymphocyte Count;
China/epidemiology*;
Female;
HIV/drug effects*;
HIV Infections/mortality*;
Humans;
Male;
Middle Aged;
Proportional Hazards Models;
Risk Factors;
Survival Analysis;
Survival Rate
- From:
Chinese Journal of Epidemiology
2018;39(7):966-970
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the survival of HIV/AIDS patients after receiving antiretroviral therapy for 10 year in Henan province and related factors. Methods: The database of national integrated management system of HIV/AIDS was used to collect the basic information and follow-up information of HIV/AIDS patients who received antiretroviral therapy between 2003 and 2005 in Henan province. Software SPSS 23.0 was used to analyze the patients' survival and related factors based on the life-table method and Cox proportional hazards model. Results: Among the 2 448 HIV/AIDS patients who started antiretroviral therapy during 2003-2005, the men accounted for 53.5%, and women accounted for 46.5%. Up to 70.1% of the patients were aged 40-59 years and 95.5% of the patients had blood borne infections. The patients were observed for 10 years after antiviral treatment, and 719 cases died from AIDS related diseases, with a mortality rate of 3.78/100 per year (719/19 010 per year). The cumulative survival rates of patients within 1-year, 3 years, 5 years and 10 years were 0.94, 0.86, 0.78, 0.69 respectively. Compared with the patients aged <40 years, the HRs of the patients aged 40-, 50-, 60- and ≥70 years were 1.417 (95%CI: 0.903-2.222), 1.834 (95%CI: 1.174-2.866), 2.422 (95%CI: 1.539-3.810) and 3.424 (95%CI: 2.053-5.709) respectively. Compared with patients with baseline CD(4+)T lymphocyte >350 unit/ul, the HRs of the patients with CD(4+)T lymphocyte <50 unit/μl, 50-199 unit/ul and 200-350 unit/ul were 7.105 (95%CI: 5.449-9.264), 4.175 (95%CI: 3.249-5.366) and 2.214 (95%CI: 1.691-2.900) respectively. Compared with the women, the HR of the men was 1.480 (95%CI: 1.273-1.172). Compared with the patients who received second line ART therapy, the HR of patients receiving no second line therapy was 11.923 (95%CI: 9.410-15.104). Conclusions: The cumulative survival rate the HIV/AIDS patients after 10 years of antiretroviral therapy reached 0.69 in Henan. Male, old age, low basic CD(4+)T lymphocyte count and receiving no second line therapy were the risk factors for long-term survival of AIDS patients.
