- VernacularTitle:高血压人群中体质指数与全死因死亡风险的队列研究
- Author:
X J LIU
1
;
B Y WANG
1
;
Y C REN
1
;
Y ZHAO
1
;
D C LIU
1
;
D D ZHANG
1
;
X CHEN
1
;
L L LIU
1
;
C CHENG
1
;
F Y LIU
2
;
Q G ZHOU
2
;
G Z CHEN
2
;
S H HONG
2
;
D LIU
2
;
S Q HU
2
;
M ZHANG
2
;
D S HU
1
Author Information
- Publication Type:Journal Article
- Keywords: Body mass index; Hypertension; Mortality; Obesity paradox
- MeSH: Adult; Asian People/statistics & numerical data*; Blood Pressure/physiology*; Body Mass Index; Cause of Death; China/epidemiology*; Humans; Hypertension/mortality*; Middle Aged; Mortality; Obesity/mortality*; Overweight; Prospective Studies; Risk Factors; Young Adult
- From: Chinese Journal of Epidemiology 2018;39(7):914-919
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between body mass index (BMI) and all-cause mortality in hypertensive population. Methods: All participants were selected from a prospective cohort study based on a rural population from Henan province, China. Cox proportional hazards regression models were used to estimate the associations of different levels of BMI stratification with all-cause mortality. Restricted cubic spline models were used to detect the dose-response relation. Results: Among the 5 461 hypertensive patients, a total of 31 048.38 person-years follow-up was conducted. The median of follow-up time was 6 years, and 589 deaths occurred during the follow-up period. Compared to normal weight group (18.5 kg/m(2)
%CI: 0.37-1.87), 0.81 (95%CI: 0.67-0.97), and 0.72 (95%CI: 0.56-0.91), respectively. The dose-response analysis showed a nonlinear, reverse "S" shaped relationship (non-linearity P<0.001). Conclusion: Overweight or obese might have a protective effect on all-cause mortality in hypertensive population, which supports the "obesity paradox" phenomenon.