Clinical characteristics and economic burden of influenza among children under 5 years old, in Suzhou, 2011-2017.
10.3760/cma.j.issn.0254-6450.2018.06.029
- VernacularTitle:苏州市2011-2017年5岁以下儿童流感门诊病例临床特征及疾病负担
- Author:
J YU
1
;
T ZHANG
1
;
Y WANG
1
;
J M GAO
1
;
J HUA
2
;
J M TIAN
2
;
Y F DING
2
;
J ZHANG
3
;
L L CHEN
3
;
J Q LI
2
;
G M ZHAO
1
Author Information
1. School of Public Health, Fudan University, Shanghai 200032, China.
2. Soochow University Affiliated Children's Hospital, Suzhou 215003, China.
3. Suzhou Center for Disease Control and Prevention, Suzhou 215000, China.
- Publication Type:Journal Article
- Keywords:
Children;
Clinical characteristics;
Economic burden;
Influenza
- MeSH:
Ambulatory Care/statistics & numerical data*;
Child;
Child, Preschool;
China/epidemiology*;
Cost of Illness;
Cough/virology*;
Female;
Fever/virology*;
Humans;
Infant;
Infant, Newborn;
Influenza A Virus, H1N1 Subtype;
Influenza A Virus, H3N2 Subtype;
Influenza, Human/epidemiology*;
Outpatient Clinics, Hospital/statistics & numerical data*;
Outpatients/statistics & numerical data*;
Prospective Studies;
Socioeconomic Factors;
Surveys and Questionnaires;
Virus Diseases
- From:
Chinese Journal of Epidemiology
2018;39(6):847-851
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To understand the clinical characteristics and economic burden of influenza-like illness (ILI) children aged 0-59 months in the outpatient settings in Suzhou, China, 2011-2017. Methods: From March 2011 to February 2017, we conducted a prospective surveillance program on ILI for children aged less than 5 years at Soochow University Affiliated Children's Hospital. Through standard questionnaires and follow-up survey via telephone, we collected information regarding the demographic characteristics, medical history, clinical symptoms and both direct and indirect costs associated with influenza, of the patients. We then compared clinical characteristics and economic burden of influenza A/H1N1, A/H3N2, and B infections among children with ILI. Results: We enrolled 6 310 patients with ILI from March 2011 to February 2017 and collected all their throat swabs. 791 (12.9%) of the swabs showed positive for influenza virus, including 88 (11.1%) subtype influenza A/H1N1, 288 (36.4%) subtype influenza A/H3N2, and 415(52.5%) type influenza B. The proportions of cough, rhinorrhea, wheezing, vomiting and convulsion in influenza-positive children were higher than those influenza-negative children. Except for the prevalence rates of cough (χ(2)=9.227, P=0.010), wheezing (χ(2)=7.273, P=0.026) and vomiting (χ(2)=8.163, P=0.017), other clinical symptoms appeared similar between the three viral subtypes. Among all the ILI children, the average total cost per episode of influenza was 688.4 Yuan (95%CI: 630.1-746.7) for influenza-negative children; 768.0 Yuan (95%CI: 686.8-849.3) for influenza-positive children and 738.3 Yuan (95%CI: 655.5-821.1) for influenza B. Children with influenza A/H1N1 spent much more than those with influenza A/H3N2 or influenza B in the total cost (χ(2)=7.237, P=0.028). Conclusion: Children infected influenza showed higher prevalence rates of cough, rhinorrhea, wheezing, vomiting and convulsion than those without influenza. Influenza A/H1N1 subtype caused heavier economic burden than the other two influenza subtypes.
